| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C50H54FN7O11 |
| Purity | |
| Activity | |
| SMILES | |
| Form | Solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
MC-VA-PAB-Exatecan is an agent-linker conjugate for antibody-drug conjugates (ADCs), containing the ADC linker peptide MC-VA-PAB and the DNA topoisomerase I inhibitor Exatecan. An ADC synthesized with this conjugate has shown good antitumor activity[1]. It is supplied as a light yellow to yellow solid (C50H54FN7O11, MW 948.00) at 98.88% purity.
Physical & Chemical Properties
| CAS Number | 2680543-57-9 |
|---|---|
| Molecular Formula | C50H54FN7O11 |
| Molecular Weight | 948.00 g/mol |
| Purity | 98.88% |
| Appearance | Solid |
| Color | Light yellow to yellow |
| SMILES | O=C(C=CC1=O)N1CCCCCC(N[C@@H](C(C)C)C(N[C@@H](C)C(NC(C=C2)=CC=C2COC(N[C@@H]3C4=C5C(C(N6C5)=CC([C@](O)(C(OC7)=O)CC)=C7C6=O)=NC8=CC(F)=C(C)C(CC3)=C84)=O)=O)=O)=O |
| Signaling Pathway | Antibody-Drug Conjugate/ADC Related; Cell Cycle/DNA Damage |
| Bioactivity Class | Camptothecins |
| Solubility | In Vitro: DMF: ≥ 100 mg/mL (105.49 mM) DMSO: 100 mg/mL (105.49 mM; Requires sonication; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) * "≥" means soluble, but saturation unknown. |
| Storage | -20°C, sealed storage, away from moisture and light. In solvent: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description. Peer-reviewed publications that used this product are listed under References.
[1]. KRAIEM, et al. Treatment of cancer. WO2021151984A1.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.
In Vitro
| Solvent | Solubility | Notes |
|---|---|---|
| DMF | ≥ 100 mg/mL (105.49 mM) | — |
| DMSO | 100 mg/mL (105.49 mM) | requires sonication; use freshly opened DMSO (absorbed moisture lowers solubility) |
Aliquot the stock solution and store it at -80°C (up to 6 months) or -20°C (up to 1 month); sealed storage, away from moisture and light; avoid repeated freeze-thaw cycles.
Data provided by the manufacturer.
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Patent. US20250255982A1.
