| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C59H71ClN10O10 |
| Purity | |
| SMILES | |
| Form | Solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
MC-Val-Cit-PAB-Ispinesib, also identified as Compound 509, is a drug-linker conjugate for ADCs, consisting of a cleavable ADC linker and an Eg5 inhibitor. It can be used for the synthesis of antibody-drug conjugates (ADCs)[1]. It is supplied as a white to off-white solid (C59H71ClN10O10, MW 1115.71) at 99.85% purity.
Physical & Chemical Properties
| CAS Number | 1629737-40-1 |
|---|---|
| Molecular Formula | C59H71ClN10O10 |
| Molecular Weight | 1115.71 g/mol |
| Purity | 99.85% |
| Appearance | Solid |
| Color | White to off-white |
| SMILES | O=C(C1=CC=C(C=C1)C)N(CCCNC(OCC2=CC=C(C=C2)NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCCCCN3C(C=CC3=O)=O)=O)=O)=O)=O)[C@@H](C(N4CC5=CC=CC=C5)=NC6=CC(Cl)=CC=C6C4=O)C(C)C |
| Signaling Pathway | Antibody-Drug Conjugate/ADC Related; Cell Cycle/DNA Damage; Cytoskeleton |
| Solubility | In Vitro: DMSO: 100 mg/mL (89.63 mM; Requires sonication; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) Chloroform: ≥ 100 mg/mL (89.63 mM) * "≥" means soluble, but saturation unknown. |
| Storage | -20°C, protect from light, stored under nitrogen. In solvent: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description. Peer-reviewed publications that used this product are listed under References.
[1]. Paul A. Barsanti, et al. Cell proliferation inhibitors and conjugates thereof. WO2014151030. 2014-09-25
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.
In Vitro
| Solvent | Solubility | Notes |
|---|---|---|
| DMSO | 100 mg/mL (89.63 mM) | requires sonication; use freshly opened DMSO (absorbed moisture lowers solubility) |
| Chloroform | ≥ 100 mg/mL (89.63 mM) | — |
Aliquot the stock solution and store it at -80°C (up to 6 months) or -20°C (up to 1 month); protect from light, stored under nitrogen; avoid repeated freeze-thaw cycles.
Data provided by the manufacturer.
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