| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | N-[[(1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)amino]carbonyl]-4-(1-hydroxy-1-methylethyl)-2-furansulfonamide sodium salt; CRID3; CP-456773 sodium salt |
| Cas No. | |
| Form | White powder |
| Molecular Weight | |
| Product Type | |
| Purity | |
| Shipping | |
| SMILES | |
| Solubility | May be dissolved in water (30 mg/ml): or DMSO (40 mg/ml) |
| Source | Synthetic |
| Storage |
MCC-950 is a selective inhibitor of the NLRP3 inflammasome, a key mediator of neuroinflammation. It blocks both canonical and noncanonical NLRP3 activation, reducing IL-1β secretion and attenuating neuroinflammatory responses. MCC-950 has shown therapeutic potential in models of multiple sclerosis and Parkinson’s disease, where inflammasome activation contributes to neuronal damage and disease progression. Its ability to modulate innate immune signaling makes it a promising candidate for neurodegenerative disease research.
Classification: Caution: Not a hazardous substance or mixture.
Safety Phrases:
- S22 - Do not breathe dust
- S24/25 - Avoid contact with skin and eyes
- S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
MCC-950 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-604)
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
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2. Coll R.C., et al. (2011) PLoS One. 6(12):e29539.
3. Coll R.C., et al. (2015) Nat. Med. 21(3):248-255.
4. Kaneko N., et al. (2015) J. Immunol. Methods. 426:76-81. 5. Nguyen L., et al. (2022) J Parkinsons Dis. 12(7): 2117-2133.
