| Field | Specification |
|---|---|
| Target | |
| Applications | |
| Molecular weight | |
| Molecular formula | C45H52ClN7O13 |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
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Compound Overview
MCI alleviates inflammation through macrophage reprogramming by targeting ROS scavenging and downregulating COX-2, inhibiting COX-2 with an IC50 value of 1.23 μM. It shows significant anti-inflammatory effects in collagen-induced arthritis (CIA) models and can be used in research on rheumatoid arthritis (RA)[1]. It has a molecular formula of C45H52ClN7O13 and a molecular weight of 934.39 g/mol.
Physical & Chemical Properties
| Molecular Formula | C45H52ClN7O13 |
|---|---|
| Molecular Weight | 934.39 g/mol |
| SMILES | O[C@H]1[C@H](O)[C@H](CO)OC(OCCN2C=C(C[C@H](NC(/C=C/C3=CC(O)=C(O)C=C3)=O)C(NCCCCNC(CC4=C(C)N(C(C5=CC=C(Cl)C=C5)=O)C6=CC=C(OC)C=C46)=O)=O)N=N2)[C@H]1O |
| Target | COX-2 |
| Signaling Pathway | Immunology/Inflammation; NF-κB; Metabolic Enzyme/Protease |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Biological Activity
IC50 & Target[1]
|
COX-2 1.23 μM (IC50) |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
In Vitro
In LPS-stimulated RAW 264.7 cells, MCI (8 μM, 2 h) inhibits ROS production and COX-2 expression, which results in a phenotypic transition of macrophages from the M1 state to the M2 state[1].
Immunofluorescence[1]
| Cell Line | LPS-stimulated RAW 264.7 cell |
|---|---|
| Concentration | 8 μM |
| Incubation Time | 2 h |
| Result | Inhibited the level of NF-κB p65 in the nuclei. Increased the level of CD163. |
Western Blot Analysis[1]
| Cell Line | LPS-stimulated RAW 264.7 cell |
|---|---|
| Concentration | 8 μM |
| Incubation Time | 2 h |
| Result | Inhibited COX-2 and iNOS expression. Increased arginase-1 (Arg-1) expression. |
In Vivo
Progression of RA is prevented by MCI (1.05 mg/kg, intraarticular injection, once every three days for 18 days), which also shows significant anti-inflammatory effects[1].
| Animal Model | Collagen-induced arthritis (CIA) models with BALB/c mice[1] |
|---|---|
| Dosage | 1.05 mg/kg, once every three days for 18 days |
| Administration | Intraarticularly injection |
| Result | Reduced the average ankle thickness and clinical index. Reduced cartilage damage and essentially intact like that of healthy mice. |
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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