| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | 3,4-Methylenedioxy-β-nitrostyrene; 5-[(E)-2-Nitrovinyl]-1,3-benzodioxole |
| Cas No. | |
| Form | Yellow Solid |
| Molecular Weight | |
| Product Type | |
| Purity | |
| Shipping | |
| SMILES | |
| Solubility | Soluble in 50 mg/ml DMSO |
| Source | Synthetic |
| Storage |
MDBN is an irreversible inhibitor of the AAA-ATPase p97, also known as valosin-containing protein (VCP), with an IC50 below 10 µM. p97 plays a central role in protein homeostasis, including ER-associated degradation (ERAD), autophagy, and stress granule dynamics. Mutations in p97 are linked to neurodegenerative disorders such as inclusion body myopathy and frontotemporal dementia. MDBN offers a pharmacological approach to modulate p97 activity and investigate its role in neuronal proteostasis and neurodegeneration.
Classification: Caution – Substance not yet fully tested.
Safety Phrases:
- S22 - Do not breathe dust
- S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
- S24/25- Avoid contact with skin and eyes
MDBN (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-342)
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
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equivalents, or discuss custom synthesis with the right QC documentation (RUO).
