| Field | Specification |
|---|---|
| Applications | |
| Molecular weight | |
| Molecular formula | C25H24Cl2FN3O3 |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
MDM2/4-p53-IN-3 inhibits the MDM2/4-p53 protein-protein interactions, with IC50 values of 18.5 nM for the MDM2-p53 interaction and 14.8 nM for the MDM4-p53 interaction. It can be used in the research of cancers such as colon cancer[1]. Its molecular formula is C25H24Cl2FN3O3, with a molecular weight of 504.38 g/mol.
Physical & Chemical Properties
| Molecular Formula | C25H24Cl2FN3O3 |
|---|---|
| Molecular Weight | 504.38 g/mol |
| SMILES | O=C(C([C@@H]1C2=CC=CC(Cl)=C2F)=NN(C3CCCCC3)[C@@]41C(NC5=C4C=CC(Cl)=C5)=O)OCC |
| Signaling Pathway | Apoptosis |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
In Vitro
MDM2/4-p53-IN-3 inhibits cell proliferation at 1-100 μM over 48 h[1]. It dissociates p53-MDMs complexes (immunoenzymatic assays), with IC50 values of 18.5 nM (MDM2-p53) and 14.8 nM (MDM4-p53)[1].
Cell Proliferation Assay[1]
| Cell Line | HCT116, SJSA-1, LNCaP, MCF-7 |
|---|---|
| Concentration | 1-100 μM |
| Incubation Time | 48 h (HCT116), 72 h (MCF-7), 96 h (SJSA-1, LNCaP) |
| Result | Inhibited cell proliferation with IC50 values of 23.6 μM (HCT116), 12.6 μM (SJSA-1), 13.1 μM (LNCaP), 14.3 μM (MCF-7). |
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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