| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C28H28N2O4S |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
MDM2/XIAP-IN-1 is an orally active dual inhibitor of MDM2 and XIAP, with anticancer activity showing an IC50 value of 0.3 μM, and it can be used in cancer research[1]. It has a molecular formula of C28H28N2O4S and a molecular weight of 488.60 g/mol.
Physical & Chemical Properties
| CAS Number | 359595-95-2 |
|---|---|
| Molecular Formula | C28H28N2O4S |
| Molecular Weight | 488.60 g/mol |
| SMILES | O=C(OC)C1=CC=C(C2NC3=C(C=C(S(=O)(NC4=CC=C(C)C(C)=C4)=O)C=C3)C5C2CC=C5)C=C1 |
| Signaling Pathway | Apoptosis |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Biological Activity
IC50 & Target
IC50:0.3 μM (EU-1 cell)[1]
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
[1]. Zhongzhi Wu, et al. Discovery of N-(3,4-Dimethylphenyl)-4-(4-isobutyrylphenyl)-2,3,3a,4,5,9b-hexahydrofuro[3,2-c]quinoline-8-sulfonamide as a Potent Dual MDM2/XIAP Inhibitor. Med. Chem. 2021, 64, 4.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
In Vitro
MDM2/XIAP-IN-1 (0-4 μM, 48 h) inhibits cell viability in two ALL cell lines, EU-1 and EU-3, as well as three NB cell lines, NB-1643, SHEP1, and LA1-55N[1]. MDM2/XIAP-IN-1 degrades MDM2 and XIAP and kills tumor cells in a targeted manner, without toxicity to normal cells[1].
Clonogenic Assay：
| Cell Line | NB and normal human hematopoietic cells[1] |
|---|---|
| Concentration | 0-4 μM |
| Incubation Time | 2 weeks |
| Result | Inhibited tumor cell growth, non-toxic to normal human hematopoietic cells. |
Western Blot Analysis
| Cell Line | EU-1 cell[1] |
|---|---|
| Concentration | 0-2 μM |
| Incubation Time | 0-24 h |
| Result | Caused the MDM2 and XIAP degradation as well as inducted p53 expression. |
In Vivo
Pharmacokinetic analysis of MDM2/XIAP-IN-1 in a male SD rat model[1]
| Route | Dose (mg/kg) | AUClast (ng·h/mL) | t1/2 (h) | Clobs (L·h/kg) | F (%) |
| i.v. | 10 | 4750 | 0.94 | 2.12 | / |
| p.o. | 25 | 0.71 | / | / | 5.9% |
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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