| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C16H18Cl2N2O4 |
| Purity | |
| SMILES | |
| Form | Solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
Mefenpyr-diethyl is a pyrazoline-type herbicide safener that enhances lipid biosynthesis. It effectively prevents herbicide-induced phytotoxic damage from herbicides such as fenoxaprop-p-ethyl and mesosulfuron-methyl, protecting cereal crops including wheat, and it significantly raises lipid content in wheat whether applied alone or together with fenoxaprop-p-ethyl. Its mechanism of action does not involve induction of glutathione S-transferase (GST) activity in wheat[1][2]. It is supplied as an off-white to light yellow solid (C16H18Cl2N2O4, MW 373.23) at 99.45% purity.
Physical & Chemical Properties
| CAS Number | 135590-91-9 |
|---|---|
| Molecular Formula | C16H18Cl2N2O4 |
| Molecular Weight | 373.23 g/mol |
| Purity | 99.45% |
| Appearance | Solid |
| Color | Off-white to light yellow |
| SMILES | O=C(C1=NN(C2=CC=C(Cl)C=C2Cl)C(C(OCC)=O)(C)C1)OCC |
| Signaling Pathway | Metabolic Enzyme/Protease |
| Solubility | In Vitro: DMSO: 100 mg/mL (267.93 mM; Requires sonication; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) |
| Storage | 4°C, protect from light. In solvent: -80°C, 6 months; -20°C, 1 month (protect from light). |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
[1]. Cataneo A C, et al. Mefenpyr-diethyl action on fenoxaprop-p-ethyl detoxification in wheat varieties[J]. Planta Daninha, 2013, 31(2): 387-393.
[2]. Wu Z, et al. Enantioselective separation and determination of mefenpyr‑diethyl enantiomers in cereals and soil using high-performance liquid chromatography-tandem mass spectrometry[J]. Journal of Chromatography Open, 2023, 3: 100085.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.
In Vitro
| Solvent | Solubility | Notes |
|---|---|---|
| DMSO | 100 mg/mL (267.93 mM) | requires sonication; use freshly opened DMSO (absorbed moisture lowers solubility) |
Aliquot the stock solution and store it at -80°C (up to 6 months) or -20°C (up to 1 month); protect from light; avoid repeated freeze-thaw cycles.
In Vivo
Choose the formulation that suits the animal model and route of administration; percentages are volume ratios of the final working solution. Start from a clear DMSO stock (see In Vitro above), add the co-solvents one at a time in the order listed, mixing after each addition, and prepare the working solution fresh on the day of dosing. If precipitation or phase separation occurs, gentle warming or sonication can help.
Protocol 1
| Composition | 10% DMSO + 40% PEG300 + 5% Tween-80 + 45% saline |
|---|---|
| Result | ≥ 2.5 mg/mL (6.70 mM); clear solution |
| How to prepare | Gives a clear solution at ≥ 2.5 mg/mL (saturation not determined). For 1 mL of working solution: add 100 μL DMSO stock (25.0 mg/mL) to 400 μL PEG300; then 50 μL Tween-80; then 450 μL saline to bring the volume to 1 mL. Saline: dissolve 0.9 g sodium chloride in ddH2O and make up to 100 mL. |
Protocol 2
| Composition | 10% DMSO + 90% (20% SBE-β-CD in saline) |
|---|---|
| Result | 2.5 mg/mL (6.70 mM); suspension; requires sonication |
| How to prepare | Gives a suspension at 2.5 mg/mL. The suspension is suitable for oral and intraperitoneal dosing. For 1 mL of working solution: add 100 μL DMSO stock (25.0 mg/mL) to 900 μL 20% SBE-β-CD in saline. 20% SBE-β-CD in saline: dissolve 2 g SBE-β-CD powder in 10 mL saline until clear (4°C, store up to one week). |
Protocol 3
| Composition | 10% DMSO + 90% Corn Oil |
|---|---|
| Result | ≥ 2.5 mg/mL (6.70 mM); clear solution |
| How to prepare | Gives a clear solution at ≥ 2.5 mg/mL (saturation not determined). Use with caution if continuous dosing will exceed two weeks. For 1 mL of working solution: add 100 μL DMSO stock (25.0 mg/mL) to 900 μL corn oil. |
Data provided by the manufacturer.
In Vitro
In wheat cultivars (BRS 49, CD 104, CEP 24, IAPAR 78 and Rubi), Mefenpyr-diethyl (18.75 g ha-1; 7 and 14 days after application), alone or mixed with fenoxaprop-p-ethyl, prevents herbicide-induced phytotoxicity, and no damage is seen at 7 and 14 days after application[1]. In the same cultivars (BRS 49, CD 104, CEP 24, IAPAR 78, and Rubi), glutathione S-transferase (GST) activity is altered at 7 days after application of Mefenpyr-diethyl (18.75 g ha-1)[1].
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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