| Field | Specification |
|---|---|
| Target | |
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C36H37F5IN9O6 |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
MEK/PI3K-IN-1 is a potent MEK/PI3K inhibitor with IC50 values of 124 nM against MEK1, 130 nM against PI3Kα, and 236 nM against PI3Kδ. It suppresses pAKT and pERK1/2 levels and displays anti-proliferative activity against tumor cell lines[1]. It has a molecular formula of C36H37F5IN9O6 and a molecular weight of 913.63 g/mol.
Physical & Chemical Properties
| CAS Number | 2281803-28-7 |
|---|---|
| Molecular Formula | C36H37F5IN9O6 |
| Molecular Weight | 913.63 g/mol |
| SMILES | O=C(C1=C(C(F)=C(C=C1)F)NC2=CC=C(C=C2F)I)NOCCOCCOCCOCCNC3=NC(N4CCOCC4)=NC(N5C(C(F)F)=NC6=C5C=CC=C6)=N3 |
| Target | MEK1, PI3Kα, PI3Kδ, PI3Kβ, PI3Kγ |
| Signaling Pathway | MAPK/ERK Pathway; PI3K/Akt/mTOR; Cell Cycle/DNA Damage |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Biological Activity
IC50 & Target
|
MEK1 124 ± 11 nM (IC50) |
PI3Kα 130 ± 13 nM (IC50) |
PI3Kδ 236 ± 29 nM (IC50) |
PI3Kβ 1537 ± 188 nM (IC50) |
PI3Kγ 2745 ± 485 nM (IC50) |
Literature Cited
Sources cited in this description. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
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