| Field | Specification |
|---|---|
| Target | |
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C38H41F5IN9O7 |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
MEK/PI3K-IN-2 is a potent MEK/PI3K inhibitor with IC50 values of 352 nM against MEK1, 107 nM against PI3Kα, and 137 nM against PI3Kδ. It suppresses pAKT and pERK1/2 levels and shows anti-proliferative activity against tumor cell lines[1]. It has a molecular formula of C38H41F5IN9O7 and a molecular weight of 957.68 g/mol.
Physical & Chemical Properties
| CAS Number | 2281803-33-4 |
|---|---|
| Molecular Formula | C38H41F5IN9O7 |
| Molecular Weight | 957.68 g/mol |
| SMILES | O=C(C1=C(C(F)=C(C=C1)F)NC2=CC=C(C=C2F)I)NOCCOCCOCCOCCN(C3=NC(N4CCOCC4)=NC(N5C(C(F)F)=NC6=C5C=CC=C6)=N3)CCO |
| Target | MEK1, PI3Kα, PI3Kδ, PI3Kγ, PI3Kβ |
| Signaling Pathway | MAPK/ERK Pathway; PI3K/Akt/mTOR; Cell Cycle/DNA Damage |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Biological Activity
IC50 & Target
|
MEK1 352 ± 2 nM (IC50) |
PI3Kα 107 ± 21 nM (IC50) |
PI3Kδ 137 ± 7 nM (IC50) |
PI3Kγ 2567 ± 364 nM (IC50) |
PI3Kβ 3880 ± 725 nM (IC50) |
Literature Cited
Sources cited in this description. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
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