| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C33H27FN4O4 |
| Purity | |
| SMILES | |
| Form | Solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
MET kinase-IN-2 is a potent, selective, orally bioavailable MET kinase inhibitor with an IC50 of 7.4 nM, and it has antitumor activity[1]. It is supplied as an off-white to light yellow solid (C33H27FN4O4, MW 562.59) at 98.08% purity.
Physical & Chemical Properties
| CAS Number | 2101241-90-9 |
|---|---|
| Molecular Formula | C33H27FN4O4 |
| Molecular Weight | 562.59 g/mol |
| Purity | 98.08% |
| Appearance | Solid |
| Color | Off-white to light yellow |
| SMILES | O=C1C(C2=CC=CC=C2)=CNC3=C1C(NC4=CC=C(OC5=CC=NC6=CC(OCC(C)(O)C)=CC=C56)C(F)=C4)=NC=C3 |
| Signaling Pathway | Protein Tyrosine Kinase/RTK |
| Solubility | In Vitro: DMSO: 100 mg/mL (177.75 mM; Requires sonication; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) |
| Storage | 4°C, protect from light, stored under nitrogen. In solvent: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.
In Vitro
| Solvent | Solubility | Notes |
|---|---|---|
| DMSO | 100 mg/mL (177.75 mM) | requires sonication; use freshly opened DMSO (absorbed moisture lowers solubility) |
Aliquot the stock solution and store it at -80°C (up to 6 months) or -20°C (up to 1 month); protect from light, stored under nitrogen; avoid repeated freeze-thaw cycles.
Data provided by the manufacturer.
In Vitro
MET kinase-IN-2 (72 hours) inhibits the U-87 MG, NIH-H460, HT-29, and MKN-45 cell lines, with IC50s of 2.9 to 4.5 μM[1]. Against AXL, Flt4, KDR, Mer, TEK, and TYRO3, MET kinase-IN-2 shows IC50s from 16.5 to 198 nM[1].
In Vivo
MET kinase-IN-2 (dosed p.o. at 3-37.5 mg/kg, 7 days per week for 3 weeks) shows statistically significant tumor growth inhibition in the U-87 MG 24 xenograft model[1]. Upon MET kinase-IN-2 treatment, Cmax, AUC0-∞, T1/2, CL, and F% are 1.5 μg/mL, 10.7 μg•h/mL, 4.9 hours, 0.5 L/h/kg, and F=32%, respectively[1].
| Animal Model | 4-6 weeks old Female nude mice (U-87 MG xenograft model)[1] |
|---|---|
| Dosage | 3, 6, 12.5, 37.5 mg/kg |
| Administration | P.o.; 7 days per week for 3 weeks |
| Result | Induced dose-dependent tumor growth inhibition. |
| Animal Model | Male SD rats[1] |
|---|---|
| Dosage | 5 mg/kg |
| Administration | P.o. (Pharmacokinetic Analysis) |
| Result | Displayed favorable overall PK profiles, with maximal plasma concentration (Cmax=1.5 μg/mL, 5-fold higher to that of IV), plasma exposure (AUC0-∞=10.7 μg•h/mL, 9.7-fold higher to that of IV), half-life (T1/2=4.9 h, 4.9-fold longer to that of IV), total clearance CL (0.5 L/h/kg; 10-fold lower to that of IV), and oral bioavailability (F=32%, 2.7-fold higher to that of IV) after oral dose of 5 mg/kg (10 mg/kg for IV). |
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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