| Field | Specification |
|---|---|
| Alternative names | N,N-Dimethylimidodicarbonimidic diamide hydrochloride |
| CAS no. | |
| Applications | |
| Source | Synthetic |
| Molecular weight | |
| Molecular formula | C4H11N5•HCl |
| Purity | |
| Bioactivity | Inducer |
| Activity | |
| Solubility | Soluble to 100 mM in water and to 50 mM in DMSO. |
| SMILES | |
| InChIKey | |
| Form | White crystalline powder. |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Metformin Hydrochloride is a widely used antidiabetic agent that improves insulin sensitivity and lowers blood glucose levels. In neuroscience, Metformin has emerged as a promising neuroprotective compound. It activates the LKB1-AMPK pathway, which inhibits mTORC1 and promotes autophagy—a key mechanism for clearing misfolded proteins and damaged organelles in neurons. Metformin has been shown to reduce alpha-synuclein phosphorylation and aggregation, making it relevant in Parkinson’s disease research. It also exhibits anti-inflammatory and antioxidant effects, contributing to its potential in Alzheimer’s disease and other neurodegenerative conditions. Metformin’s ability to modulate energy metabolism and cellular stress responses positions it as a candidate for therapeutic repurposing in brain aging and neurodegeneration.
Classification: D2B- Toxic Material Causing Other Toxic Effects, Moderate skin irritant, Moderate eye irritant
Safety Phrases:
- S22 - Do not breathe dust.
- S24/25 - Avoid contact with skin and eyes.
- S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
Hazard statements:
- H302- Harmful if swallowed.
- H315- Causes skin irritation.
- H319- Causes serious eye irritation.
Precautionary statements:
P305 + P351 + P338- IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Metformin Hydrochloride (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-395)
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
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2. Caton P. W., et al. (2010). J Endocrino;. 205(1): 97-106.
3. Feng Y. H., et al. (2011). J Cell Mol Med. 15(4): 825-36.
4. Huang H., et al. (2013). Autophagy. 9(2): 175-95.
