Metformin Hydrochloride

Metformin Hydrochloride is a widely used antidiabetic agent that improves insulin sensitivity and lowers blood glucose levels. In neuroscience, Metformin has emerged as a promising neuroprotective compound. It activates the LKB1-AMPK pathway, which inhibits mTORC1 and promotes autophagy—a key mechanism for clearing misfolded proteins and damaged organelles in neurons. Metformin has been shown to reduce alpha-synuclein phosphorylation and aggregation, making it relevant in Parkinson’s disease research. It also exhibits anti-inflammatory and antioxidant effects, contributing to its potential in Alzheimer’s disease and other neurodegenerative conditions. Metformin’s ability to modulate energy metabolism and cellular stress responses positions it as a candidate for therapeutic repurposing in brain aging and neurodegeneration.

Classification: D2B- Toxic Material Causing Other Toxic Effects, Moderate skin irritant, Moderate eye irritant

Safety Phrases:

• S22 - Do not breathe dust.
• S24/25 - Avoid contact with skin and eyes.
• S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.

Hazard statements:

• H302- Harmful if swallowed.
• H315- Causes skin irritation.
• H319- Causes serious eye irritation.

Precautionary statements:

P305 + P351 + P338- IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Metformin Hydrochloride (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-395)

Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.

• Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
• Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
• Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
• QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
• Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity

To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).

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Send the CAS or structure and your specs. We can help source it, suggest close equivalents, or discuss custom synthesis with the right QC documentation (RUO).