| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C23H22FN5O2S |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
METTL3-IN-5 is an inhibitor of METTL3 that suppresses MOLM-13 cell growth with an IC50 below 2 μM. It shows only weak inhibitory activity against hERG (IC50 >30 μM) and can be used in AML research[1]. It has the molecular formula C23H22FN5O2S and a molecular weight of 451.52 g/mol.
Physical & Chemical Properties
| CAS Number | 2965311-25-3 |
|---|---|
| Molecular Formula | C23H22FN5O2S |
| Molecular Weight | 451.52 g/mol |
| SMILES | O=C1C=C(C(NCC2=CC3=C(C=C(CNCC45CC(C4)(C5)F)N3)S2)=O)N=C6C=CC=CN16 |
| Signaling Pathway | Epigenetics |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description. Peer-reviewed publications that used this product are listed under References.
[1]. Zhong Chen, et al. Mettl3 inhibitor and composition, and application of same in medicine. WO2023151697 A1.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
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