| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | 4'-N-Benzoyl-staurosporine, PKC-412, CGP 41251 |
| Cas No. | |
| Form | White to off-white powder |
| Molecular Weight | |
| Product Type | |
| Purity | |
| Shipping | |
| SMILES | |
| Solubility | Soluble in DMSO (15 mg/ml), MDC (10 mg/ml), methanol (5 mg/ml) or 100% ethanol (2.5 mg/ml) |
| Source | Synthetic |
| Storage |
Midostaurin is a broad-spectrum protein kinase inhibitor with activity against PKC isoforms (α, β, γ), Flk, and c-Kit. In neurodegenerative disease research, Midostaurin is used to investigate the role of PKC and related kinases in neuronal signaling, apoptosis, and inflammation. Its ability to induce apoptosis and inhibit proliferative signaling pathways makes it a valuable tool for studying neurodegeneration, particularly in models involving aberrant kinase activity and glial activation.
Classification: Not a hazardous substance or mixture.
Safety Phrases:
- S22 - Do not breathe dust.
- S24/25 - Avoid contact with skin and eyes.
- S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
Midostaurin (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-468)
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
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2. Odgerel, T., et al. (2008) Oncogene. 27(22): 3102–3110.
3. Bahlis, N.J., et al. (2005) Leukemia & Lymphoma. 46(6): 899–908.
