| Field | Specification |
|---|---|
| Applications | |
| Molecular weight | |
| Molecular formula | C65H64Cl2O6P2 |
| Purity | |
| SMILES | |
| Form | Solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
MitoCur-1 is a curcumin analogue that inhibits the mitochondrial antioxidant enzyme thioredoxin reductase 2 (TrxR2). It combines electrophilic reactivity with mitochondrial targeting, and it triggers generation of reactive oxygen species (ROS) that underlies its specific antitumor efficacy[1]. It is supplied as a light yellow to orange solid (C65H64Cl2O6P2, MW 1074.05) at ≥95.0% purity.
Physical & Chemical Properties
| Molecular Formula | C65H64Cl2O6P2 |
|---|---|
| Molecular Weight | 1074.05 g/mol |
| Purity | ≥95.0% |
| Appearance | Solid |
| Color | Light yellow to orange |
| SMILES | O=C(C(C(/C=C/C1=CC=C(OCCC[P+](C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4)C(OC)=C1)=O)(C)C)/C=C/C5=CC(OC)=C(OCCC[P+](C6=CC=CC=C6)(C7=CC=CC=C7)C8=CC=CC=C8)C=C5.[Cl-].[Cl-] |
| Signaling Pathway | Metabolic Enzyme/Protease |
| Storage | 4°C, sealed storage, away from moisture and light. In solvent: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.
In Vitro
MitoCur-1 is selectively cytotoxic to HepG2 and L02 cells, with IC50s of 1.4 μM and 9.1 μM, respectively[1]. In HepG2 cells, 10 μM MitoCur-1 for 12 h generates ROS and depletes GSH, an effect selective over L02 cells[1]. At 10 μM for 24 h, MitoCur-1 arrests the cell cycle at the G0/G1 phase and inhibits cyclin protein expression[1].
Western Blot Analysis[1]
| Cell Line | HepG2 cells |
|---|---|
| Concentration | 2.5 μM, 5 μM, and 10 μM |
| Incubation Time | 24 h, 36 h, and 48 h |
| Result | Decreased the protein level of CDK2 and CDK4, Cyclin E1/D1/A2. |
Immunofluorescence[1]
| Cell Line | HepG2 and L02 cells |
|---|---|
| Concentration | 10 μM |
| Incubation Time | 12 h |
| Result | Showed selectivity on HepG2 cells over L02 cells to generates ROS. Promoted mitochondrial O2- production. |
Cell Viability Assay[1]
| Cell Line | HepG2 cells |
|---|---|
| Concentration | 1.25 μM, 2.5 μM, 5 μM, and 10 μM |
| Incubation Time | 48 h; pretreated with 400 μM DTT or not |
| Result | Inhibited HepG2 cells viability. Showed significant reversion with DTT for 1 h pretreatment. |
In Vivo
MitoCur-1 inhibits tumor growth in a mouse model without affecting body weight when given i.p. at 5 mg/kg and 15 mg/kg every other day for 4 weeks[1].
| Animal Model | BALB/c nude mice bearing HepG2 tumor[1] |
|---|---|
| Dosage | 5 mg/kg, 15 mg/kg |
| Administration | Intraperitoneal injection; every other day for 4 weeks |
| Result | Decreased the tumor growth in vivo. |
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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TrxR2 Lactylation Facilitates Mitochondrial Protection and Endothelial Ferroptosis Resistance in Diabetic Cardiomyopathy. Adv Sci (Weinh) 2026 Apr;13(22):e21997. PMID: 41704008
