| Field | Specification |
|---|---|
| Target | |
| Alternative names | Mitofusin 2, MFN2, Mfn2, Mitofusin-2, Transmembrane GTPase MFN2, Mitochondrial assembly regulatory factor, MARF, CMT2A, CMT2A2, CPRP1, CPRP 1, Fzo, HSG, Hyperplasia suppressor gene, Hypertension related protein 1, KIAA0214 |
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| Immunogen | Fusion protein amino acids 370-600 (cytoplasmic N-terminus) of mouse Mitofusin-2. Rat: 97% identity (226/231 amino acids identical). Human: 92% identity (214/231 amino acids identical) ~55% identity with Mitofusin-1. |
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Mitofusin 2 (Mfn2) is a mitochondrial membrane protein that regulates mitochondrial fusion, bioenergetics, and inter-organelle communication. It plays a vital role in maintaining mitochondrial integrity and function in neurons, which are highly dependent on energy metabolism.
Loss or dysfunction of Mfn2 impairs mitochondrial dynamics, leading to fragmented mitochondria, disrupted membrane potential, and increased oxidative stress. These mitochondrial abnormalities are implicated in neurodegenerative diseases such as Charcot-Marie-Tooth disease type 2A, Alzheimer’s disease, and Parkinson’s disease.
Mfn2 also modulates mitochondrial transport along axons and participates in mitophagy, the selective degradation of damaged mitochondria. Its role in regulating apoptosis and inflammation further underscores its importance in neuronal survival.
Targeting Mfn2 to restore mitochondrial dynamics and function represents a promising strategy for mitigating neurodegenerative processes and enhancing neuronal resilience.
1 µg/ml of SMC-457 was sufficient for detection of Mitofusin-2 in 20 µg of mouse cardiac mitochondrial lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Cite this product varies by variant:
- SMC-457D — Size: 100 ug: Mitofusin 2 Antibody (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-457D, RRID: AB_2701973)
- SMC-457D-A390 — Size: 100 ug: Mitofusin 2 Antibody: ATTO 390 (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-457D-A390, RRID: AB_2701974)
- SMC-457D-A488 — Size: 100 ug: Mitofusin 2 Antibody: ATTO 488 (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-457D-A488, RRID: AB_2701975)
- SMC-457D-A594 — Size: 100 ug: Mitofusin 2 Antibody: ATTO 594 (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-457D-A594, RRID: AB_2701977)
- SMC-457D-APC — Size: 100 ug: Mitofusin 2 Antibody: APC (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-457D-APC, RRID: AB_2701983)
- SMC-457D-BI — Size: 100 ug: Mitofusin 2 Antibody: Biotin (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-457D-BI, RRID: AB_2701984)
- SMC-457D-FITC — Size: 100 ug: Mitofusin 2 Antibody: FITC (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-457D-FITC, RRID: AB_2701985)
- SMC-457D-HRP — Size: 100 ug: Mitofusin 2 Antibody: HRP (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-457D-HRP, RRID: AB_2701986)
- SMC-457D-PCP — Size: 100 ug: Mitofusin 2 Antibody: PerCP (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-457D-PCP, RRID: AB_2701988)
- SMC-457D-RPE — Size: 100 ug: Mitofusin 2 Antibody: RPE (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-457D-RPE, RRID: AB_2701989)
- SMC-457S — Size: 12 ug: Mitofusin 2 Antibody (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-457S, RRID: AB_2701973)
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
