| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C22H31F3N2O3 |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
MK-4541 is an orally active, selective modulator of the androgen receptor (AR) that acts as an antagonist to inhibit 5α-reductase. It inhibits proliferation and induces apoptosis in AR-positive prostate cancer cells, and it significantly inhibited the growth of R3327-G prostate tumors in a xenograft mouse model[1]. It has the molecular formula C22H31F3N2O3 and a molecular weight of 428.49 g/mol.
Physical & Chemical Properties
| CAS Number | 796885-38-6 |
|---|---|
| Molecular Formula | C22H31F3N2O3 |
| Molecular Weight | 428.49 g/mol |
| SMILES | C[C@@]12[C@]3([H])[C@](CC[C@@]1([H])N(C(C=C2)=O)C)([H])[C@@]4([H])[C@@](C)([C@@H](NC(OCC(F)(F)F)=O)CC4)CC3 |
| Signaling Pathway | Vitamin D Related/Nuclear Receptor; Metabolic Enzyme/Protease |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
In Vivo
In athymic nude mice bearing R-3327-G cells, MK-4541 (100 mg/kg; p.o.; 5 times per week for 5 weeks) suppresses prostate tumor growth[1]. MK-4541 (p.o.; 100 mg/kg, 200 mg/kg; 5 times per week for 5 weeks) has anti-androgen effects on the seminal vesicles, lowers plasma testosterone concentrations in intact males, and inhibits Ki67 expression[1]. In adult castrated mice, MK-4541 (p.o.; 15 mg/kg, 50 mg/kg; 5 times per week for 8 weeks) causes loss of musculoskeletal mass and function[1].
| Animal Model | R3327-G prostate tumors in xenograft mouse model[1] |
|---|---|
| Dosage | 25 mg/kg, 50 mg/kg, 100 mg/kg, 200 mg/kg |
| Administration | Oral gavage; once daily, 5 times per week for 5 weeks |
| Result | Significantly inhibited tumor growth at 100 mg/kg, as well as reducing plasma testosterone concentration and Ki67 expression. |
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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