| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C19H17BrF4N6O6 |
| Purity | |
| SMILES | |
| Form | Solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
MK-8245 Trifluoroacetate is a liver-targeting inhibitor of stearoyl-CoA desaturase (SCD), with an IC50 of 1 nM for human SCD1 and 3 nM for both rat and mouse SCD1, giving it anti-diabetic and anti-dyslipidemic efficacy[1]. Chemically a phenoxy piperidine isoxazole derivative, it carries a tetrazole acetic acid moiety that is key to recognition by OATP transporters and to its liver targeting. In a rat hepatocyte assay containing functional OATPs it shows an IC50 of 68 nM, whereas in the OATP-deficient HepG2 cell assay it is only weakly active (IC50 ~1 μM), and it is highly selective for SCD over the Δ-5 and Δ-6 desaturases (>100000 μM against rat and human Δ5D and Δ6D)[1].
In mice dosed at 10 mg/kg, MK-8245 Trifluoroacetate concentrates in the liver, with a liver-to-Harderian gland ratio of 21 compared with 1.5 for a systemically distributed compound. Oral dosing in mice, rats, dogs and rhesus monkeys shows distribution mainly to the liver with low exposure in tissues linked to adverse events, giving liver-to-skin ratios greater than 30:1 in all four species. In eDIO mice, it improves glucose clearance before a glucose challenge in a dose-dependent manner, with an ED50 of 7 mg/kg. It is supplied as a light yellow to yellow solid (C19H17BrF4N6O6, MW 581.27) at 98.45% purity.
Physical & Chemical Properties
| CAS Number | 1415559-41-9 |
|---|---|
| Molecular Formula | C19H17BrF4N6O6 |
| Molecular Weight | 581.27 g/mol |
| Purity | 98.45% |
| Appearance | Solid |
| Color | Light yellow to yellow |
| SMILES | O=C(CN1N=C(N=N1)C2=CC(N3CCC(CC3)OC4=CC(F)=CC=C4Br)=NO2)O.FC(C(O)=O)(F)F |
| Signaling Pathway | Metabolic Enzyme/Protease |
| Storage | 4°C, sealed storage, away from moisture. In solvent: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.
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