ML 218 hydrochloride

Product details

• Chemical name: 3,5-Dichloro-N-[[(1α,5α,6-exo,6α)-3-(3,3-dimethylbutyl)-3-azabicyclo[3.1.0]hex-6-yl]methyl]-benzamide hydrochloride.
• Also known as: MLS003431854, SMR002112449, VU0413807-1, VU0413807-2, VU0424199-1
• CAS number: 1346233-68-8
• Molecular formula: C19H26Cl2N2O•HCl.
• Purity: >98%
• Concentration: 0.1-100 µM.
• Form: Lyophilized powder.
• Solubility: 100 mM in DMSO. Centrifuge all product preparations before use (10000 x g for 1 min).
• Reconstitution: 100 mM in DMSO. Centrifuge all product preparations before use (10000 x g for 1 min).
• Shipping: Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
• Target: T-type CaV channels
• Source: Synthetic
• Activity: ML 218 is a blocker of T-type Ca2+ channels (IC50 values are 270 and 310 nM for CaV3.3 and CaV3.2 respectively)1.
• Alternative names: MLS003431854, SMR002112449, VU0413807-1, VU0413807-2, VU0424199-1

Scientific background

T-Type Ca2+ channel inhibitors hold tremendous therapeutic potential for the treatment of pain, epilepsy, sleep disorders, essential tremor, and other neurological disorders1. ML 218 is a selective, potent inhibitor of T-type Ca2+ channels (IC50 values are 270 and 310 nM for CaV3.3 and CaV3.2 respectively in a patch EP assay). It has no activity on other members of the Ca2+ family of ion channels (L- and N-type Ca2+ channels) as well as multiple Na+ and K+ channels. ML 218 was found to be non-selective against hERG and many other ion channels. ML 218 possess excellent DMPK properties, acceptable in vivo rat PK, excellent brain levels and was efficacious in a haloperidol-induced catalepsy assay, a preclinical Parkinsonian model. ML 218 decreases burst activity in subthalamic nucleus (STN) neurons. Thus, ML 218 is a powerful new probe to study T-Type Ca2+ function both in vitro and in vivo2.

Lead time: 1-2 Business Days

Country of origin: Israel/IL

Applications key

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

Bioassay tested: Yes

• SDS (PDF)

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