| Field | Specification |
|---|---|
| Target | |
| CAS no. | |
| Applications | |
| Source | Synthetic |
| Molecular formula | C27H27ClN4O5. |
| Purity | |
| Activity | |
| Reconstitution | |
| Solubility | Soluble in DMSO.Centrifuge all products before handling (10000 x g 5 min). |
| Concentration | |
| Form | Lyophilized Powder |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Product details
- Chemical name: (2S)-2-[[1-(7-chloroquinolin-4-yl)-2-(2,6-dimethoxyphenyl)imidazole-4-carbonyl]amino]-4-methylpentanoic acid.
- Also known as: ML301
- CAS number: 1531633-84-7
- Molecular formula: C27H27ClN4O5.
- Purity: >98%
- Concentration: 1 nM - 1 µM.
- Form: Lyophilized Powder
- Solubility: Soluble in DMSO.Centrifuge all products before handling (10000 x g 5 min).
- Reconstitution: Soluble in DMSO.Centrifuge all products before handling (10000 x g 5 min).
- Shipping: Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
- Target: Neurotensin Receptor 1
- Source: Synthetic
- Activity: ML-301 is a selective agonist of NTR1 receptors, shown to stimulate NTR1-mediated calcium mobilization with EC50 of 289 nM1-2.
- Alternative names: ML301
Scientific background
ML-301 is a fully selective imidazole-based agonist of neurotensin receptor 1 (NTR1). It stimulates NTR1-mediated calcium mobilization with an EC50 value of 289 nM1. The carboxylic acid moiety increases the compound's solubility1.To date, four neurotensin receptors have been cloned from human: NTR1, NTR2, NTR3 and NTR4 which belong to the super family of G-protein coupled receptors (GPCRs). NTR1 mediates most of the known neurotensin ligand effects and is a potential therapeutic target2.
Lead time: 1-2 Business Days
Country of origin: Israel/IL
Applications key
Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.
Bioassay tested: Yes
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- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
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