| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Cas No. | |
| Concentration | |
| Form | Lyophilized Powder |
| Product Type | |
| Purity | |
| Reconstitution | |
| Shipping | |
| Solubility | Soluble to 100 mM in DMSO. Spin down all products before handling. |
| Source | Synthetic |
| Storage | |
| Target |
Product details
- Chemical name: 1-(4-methoxyphenyl)-~{N}-(naphthalen-1-ylmethyl)methanamine; hydrochloride.
- Also known as: ML133 HCl, N-(4-methoxybenzyl)-1-(naphthalen-1-yl)methanamine hydrochloride
- CAS number: 1222781-70-5
- Molecular formula: C19H19NO · HCl.
- Purity: >97%
- Concentration: 1-20 µM.
- Form: Lyophilized Powder
- Solubility: Soluble to 100 mM in DMSO. Spin down all products before handling.
- Reconstitution: Soluble to 100 mM in DMSO. Spin down all products before handling.
- Shipping: Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
- Target: Kir2 channels
- Source: Synthetic
- Activity: ML133 hydrochloride selectively inhibits Kir2 inward-rectifier potassium channels with IC50 values of 1.8, 2.8, 2.9 and 4.0 μM for Kir2.1, Kir2.6, Kir2.2 and Kir2.3, respectively (at pH 7.4), and with little or no effect on Kir4.1, Kir7.1 or Kir1.1 channels.1
- Alternative names: ML133 HCl, N-(4-methoxybenzyl)-1-(naphthalen-1-yl)methanamine hydrochloride
Scientific background
ML133 hydrochloride is a selective small molecule that acts as an inhibitor of Kir2 inward rectifier potassium channels. The compound blocks Kir2.1, Kir2.6, Kir2.2 and Kir2.3 and shows little or no effect on other Kir channels1. ML133 hydrochloride demonstrates IC50 values of 1.8, 2.8, 2.9 and 4.0 μM for Kir2.1, Kir2.6, Kir2.2 and Kir2.3, respectively at pH 7.41.Kir channels are a family of membrane proteins that selectively control the permeation of K+ ions across cell membranes. These channels play an important role in establishing the resting membrane potential of excitable cells, regulating pacing in cardiomyocytes and neurons, regulating pancreatic insulin secretion and renal K+ transport2.
Lead time: 1-2 Business Days
Country of origin: Israel/IL
Applications key
Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.
Bioassay tested: Yes
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- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
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