| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | ml-167, 5-[4-[[(5-Methyl-2-furanyl)methyl]amino]-6-quinazolinyl]-2-furanmethanol, CID 44968231, NCGC00188654 |
| Cas No. | |
| Form | Off-white to gray to brown |
| Molecular Weight | |
| Product Type | |
| Purity | |
| Shipping | |
| SMILES | |
| Solubility | Soluble in DMSO 10 mg/ml, clear |
| Source | Synthetic |
| Storage |
ml167 is a highly selective inhibitor of Cdc2-like kinase 4 (Clk4), a member of the Clk family involved in alternative mRNA splicing. Aberrant splicing is increasingly recognized as a contributor to neurodegenerative diseases, including ALS and frontotemporal dementia. By modulating Clk4 activity, ml167 enables the study of splicing regulation in neuronal systems and may inform therapeutic approaches targeting RNA metabolism in neurodegeneration.
Classification: Acute toxicity, Oral (Category 4), H302
Safety Phrases:
- S22 - Do not breathe dust.
- S24/25 - Avoid contact with skin and eyes.
- S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
Hazard statements:
H302 Harmful if swallowed.
Precautionary statements:
- P264 Wash skin thoroughly after handling.
- P270 Do not eat, drink or smoke when using this product.
- P301 + P312 IF SWALLOWED: Call a POISON CENTER or doctor/ physician if you feel unwell.
- P330 Rinse mouth.
- P501 Dispose of contents/ container to an approved waste disposal plant.
ml167 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-505)
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
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