| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | 1-(3,4-Difluorophenyl)-3-(3-methyl-1-phenyl-1H-pyrazol-5-yl)urea, ML297, ML 297, ML-297, VU 0456810, VU0456810-1, VU0456810-2 |
| Cas No. | |
| Form | White to beige powder |
| Molecular Weight | |
| Product Type | |
| Purity | |
| Shipping | |
| SMILES | |
| Solubility | May be dissolved in DMSO (45 mg/ml); or ethanol (20 mg/ml) |
| Source | Synthetic |
| Storage |
ML297 is a selective activator of the G protein-coupled inwardly rectifying potassium (GIRK) channels, particularly GIRK1/2. In neuroscience, ML297 has been used to study neuronal excitability, synaptic transmission, and seizure susceptibility. Its ability to modulate inhibitory signaling pathways positions it as a promising tool in epilepsy and neurodegenerative disease models involving hyperexcitability.
WHMIS Classification: Not WHMIS controlled.
GHS Classification: Acute aquatic toxicity (Category 1)
Chronic aquatic toxicity (Category 1)
Signal word:
Warning
Hazard statement(s):
H410 Very toxic to aquatic life with long lasting effects.
Precautionary statement(s):
- P273 Avoid release to the environment.
- P501 Dispose of contents/ container to an approved waste disposal plant.
ML297 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-553)
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
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