| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C43H73N5O8 |
| Purity | |
| SMILES | |
| Form | Solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
MMAF-OtBu is a modified form of MMAF that can be used in the synthesis of ADCs[1]. It is supplied as a white to off-white solid (C43H73N5O8, MW 788.07) at 99.83% purity.
Physical & Chemical Properties
| CAS Number | 745017-95-2 |
|---|---|
| Molecular Formula | C43H73N5O8 |
| Molecular Weight | 788.07 g/mol |
| Purity | 99.83% |
| Appearance | Solid |
| Color | White to off-white |
| SMILES | CC(C)(C)OC([C@H](CC1=CC=CC=C1)NC([C@H](C)[C@H]([C@@]2([H])N(CCC2)C(C[C@@H](OC)[C@H]([C@@H](C)CC)N(C)C([C@H](C(C)C)NC([C@@H](NC)C(C)C)=O)=O)=O)OC)=O)=O |
| Signaling Pathway | Antibody-Drug Conjugate/ADC Related |
| Solubility | In Vitro: DMSO: 50 mg/mL (63.45 mM; Requires sonication and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) |
| Storage | -20°C, sealed storage, away from moisture. In solvent: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
[1]. Svetlana O, et al. DoroninaMonomethylvaline compounds capable of conjugation to ligands. Patent. WO2005081711.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.
In Vitro
| Solvent | Solubility | Notes |
|---|---|---|
| DMSO | 50 mg/mL (63.45 mM) | requires sonication and warming and heat to 60°C; use freshly opened DMSO (absorbed moisture lowers solubility) |
Aliquot the stock solution and store it at -80°C (up to 6 months) or -20°C (up to 1 month); sealed storage, away from moisture; avoid repeated freeze-thaw cycles.
Data provided by the manufacturer.
In Vitro
MMAF (Monomethylauristatin F) is a potent inhibitor of tubulin polymerization and is used as an antitumor agent. MMAF (Monomethylauristatin F) is commonly used as the cytotoxic component of antibody-drug conjugates (ADCs)[1][2]. An ADC consists of an antibody carrying an ADC cytotoxin attached through an ADC linker.
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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