| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C45H73N7O8 |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
Modified MMAF is an ADC cytotoxin that can be used in the synthesis of antibody-drug conjugates (ADC). It can be used for the targeted research of cancer[1]. It has the molecular formula C45H73N7O8 and a molecular weight of 840.10 g/mol.
Physical & Chemical Properties
| CAS Number | 1352202-47-1 |
|---|---|
| Molecular Formula | C45H73N7O8 |
| Molecular Weight | 840.10 g/mol |
| SMILES | O=C(N1CCCCO1)[C@@H](NC([C@H](C)[C@H]([C@@]2([H])N(CCC2)C(C[C@@H](OC)[C@H]([C@@H](C)CC)N(C)C([C@H](C(C)C)NC([C@@H](NC)C(C)C)=O)=O)=O)OC)=O)CC3=CNC4=CC=CC=C34 |
| Signaling Pathway | Cell Cycle/DNA Damage; Cytoskeleton |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
In Vitro
In an in vitro cytotoxicity assay, MMAF inhibits anaplastic large cell lymphoma Karpas 299 cells, breast carcinoma H3396 cells, and renal cell carcinoma 786-O and Caki-1 cells, with IC50s of 119, 105, 257 and 200 nM, respectively[2].
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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