| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C34H40O9 |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
Moreollic acid inhibits PTP1B; against human targets it shows an IC50 reading of 4.44 μM alongside a Ki value of 1.75 μM. It blocks progression of the cell cycle from G1 to S phase and inhibits tumor cell proliferation, and can be used in research on type 2 diabetes, obesity, colon cancer, and other cancers[1][2]. It has the molecular formula C34H40O9 and a molecular weight of 592.68 g/mol.
Physical & Chemical Properties
| CAS Number | 173792-68-2 |
|---|---|
| Molecular Formula | C34H40O9 |
| Molecular Weight | 592.68 g/mol |
| SMILES | OC(/C(C)=C\C[C@@]12[C@@]34[C@@](C(C5=C(O)C(C=CC(C)(O6)C)=C6C(C/C=C(C)\C)=C5O4)=O)([H])[C@H]([C@@](C[C@@]3([H])C(C)(O2)C)([H])C1=O)OC)=O |
| Signaling Pathway | Metabolic Enzyme/Protease |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
In Vitro
Moreollic acid (5 μM; 48 h) strongly inhibits the viability of HCT116 human colon cancer cells (inhibition rate of 83.86%), but shows only slight or no inhibition of A549, MDA-MB-231 and KYSE30 cancer cell viability[2]. In the human colon cancer cells HCT116, DLD1 and SW620, Moreollic acid (48 h) reduces viability with IC50 values of 1.71 μM, 1.44 μM and 1.49 μM, respectively, whereas the IC50 against normal NCM460 colonic epithelial cells is higher at 3.16 μM[2].
Cell Viability Assay[2]
| Cell Line | A549, MDA-MB-231, KYSE30, HCT116 |
|---|---|
| Concentration | 5 μM |
| Incubation Time | 48 h |
| Result | Inhibited HCT116 cell viability by 83.86%. Showed minimal inhibition of A549 cell viability by 18.38%. Showed minimal inhibition of MDA-MB-231 cell viability by -4.9%. Showed minimal inhibition of KYSE30 cell viability by 20.76%. |
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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