| Field | Specification |
|---|---|
| Target | |
| Alternative names | Cirbp ELISA kit; CirpCold-inducible RNA-binding protein ELISA kit; A18 hnRNP ELISA kit; Glycine-rich RNA-binding protein CIRP ELISA kit |
| UniProt # | |
| Species | |
| Reactivity | |
| Applications | |
| Assay type | |
| Sample type(s) | serum, plasma, tissue homogenates, cell lysates |
| Sensitivity | |
| Detection range | |
| Detection wavelength | |
| Assay time | |
| Catalog no. (Mfr.) | |
| Main SKU |
Background
Cold-inducible RNA-binding protein(CIRBP) is a biological molecule commonly studied in neuroscience research. It is commonly used as a molecular readout in mechanistic and biomarker-focused studies.
UniProt: P60824
Biological context
Researchers often monitor Cold-inducible RNA-binding protein(CIRBP) in serum, plasma, tissue homogenates, and cell lysates to better understand themes such as neuronal signaling and synaptic function, neuroinflammation, and neurodegeneration models. In many model systems, measured levels can shift with physiology, experimental perturbation, or disease-associated changes, making careful biological interpretation important.
Interpreting changes in measured levels
Depending on sample matrix and study design, increases or decreases in Cold-inducible RNA-binding protein(CIRBP) may reflect differences in expression, secretion, turnover, or compartmentalization rather than a single mechanism. Interpretation is typically strengthened by evaluating related molecules (for example, synaptic proteins, neurotrophic factors, and neuroinflammatory markers) and by keeping pre-analytical variables consistent across groups.
Nomenclature
In publications and databases, Cold-inducible RNA-binding protein(CIRBP) may also appear under names such as Cirbp and CirpCold-inducible RNA-binding protein. When comparing studies, confirm that the reported analyte refers to the same molecule and species context.
Why ELISA data are widely used
ELISA is a common approach for quantitative measurement of proteins and biomarkers in complex samples, enabling comparisons across experimental groups and time points. When integrating results with other readouts, consider species biology, sample type, and the broader pathway context that Cold-inducible RNA-binding protein(CIRBP) participates in.
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Targeting CIRP and IL-6R-mediated microglial inflammation to improve outcomes in intracerebral hemorrhage
L Ye, X Tang, F Liu, T Wei, T Xu, Z Jiang, L Xu,Journal of Advanced Research,2025
CIRP increases Foxp3+ regulatory T cells and inhibits development of Th17 cells by enhancing TLR4-IL-2 signaling in the late phase of sepsis
Z Wu, X Liu, W Huang, J Chen, S Li, J Chao, J Xie, L Liu, Y Yang, X Wu, H Qiu,International Immunopharmacology,2024
Intracellular CIRP promotes liver regeneration via STAT3 signaling pathway activation after partial hepatectomy in mice
T Wang, M Wang, W Liu, L Zhang,International Journal of Molecular Medicine,2025
Blocking CIRP protects against acute pancreatitis by improving mitochondrial function and suppressing pyroptosis in acinar cells
W Liu,Cell death discovery,2024
Cold-Inducible RNA Binding Protein Impedes Breast Tumor Growth in the PyMT Murine Model for Breast Cancer
DA Lujan,Biomedicines,2024
Inhibition of the Interaction of TREM-1 and eCIRP Attenuates Inflammation and Improves Survival in Hepatic Ischemia/Reperfusion
T Borjas,Shock (Augusta, Ga.),2023
Intracellular CIRP promotes liver regeneration while extracellular CIRP induces ER stress after partial hepatectomy in mice
F Tang,/,2024
Targeting extracellular CIRP with an X-Aptamer shows therapeutic potential in acute pancreatitis
W Liu,iScience,2023
Hepatic ER stress suppresses adipose browning through ATF4-CIRP-ANGPTL3 cascade
S Lv,Cell Reports,2022
Luteolin Suppresses Sepsis-Induced Cold-Inducible RNA-Binding Protein Production and Lung Injury in Neonatal Mice
Parvathy S.,Shock,2021
Irisin reverses intestinal epithelial barrier dysfunction during intestinal injury via binding to the integrin αVβ5 receptor
Bi J, et al,Journal of Cellular and Molecular Medicine,2019
Irisin alleviates liver ischemia-reperfusion injury by inhibiting excessive mitochondrial fission, promoting mitochondrial biogenesis and decreasing oxidative stress
Bi J, et al,Redox Biology,2018
