| Field | Specification |
|---|---|
| Target | |
| Alternative names | Nlrp3 ELISA Kit; Cias1 ELISA Kit; Mmig1 ELISA Kit; Nalp3 ELISA Kit; Pypaf1 ELISA Kit; NACHT ELISA Kit; LRR and PYD domains-containing protein 3 ELISA Kit; Cold autoinflammatory syndrome 1 protein homolog ELISA Kit; Cryopyrin ELISA Kit; Mast cell maturation-associated-inducible protein 1 ELISA Kit; PYRIN-containing APAF1-like protein 1 ELISA Kit |
| UniProt # | |
| Species | |
| Reactivity | |
| Applications | |
| Assay type | |
| Sample type(s) | serum, plasma, tissue homogenates |
| Sensitivity | |
| Detection range | |
| Detection wavelength | |
| Assay time | |
| Catalog no. (Mfr.) | |
| Main SKU |
Background
NACHT, LRR and PYD domains-containing protein 3(NLRP3) is a biological molecule commonly studied in cell biology research. It is commonly used as a molecular readout in mechanistic and biomarker-focused studies.
UniProt: Q8R4B8
Biological context
Researchers often monitor NACHT, LRR and PYD domains-containing protein 3(NLRP3) in serum, plasma, and tissue homogenates to better understand themes such as signal transduction pathways, cell cycle control, and stress-response programs. In many model systems, measured levels can shift with physiology, experimental perturbation, or disease-associated changes, making careful biological interpretation important.
Interpreting changes in measured levels
Depending on sample matrix and study design, increases or decreases in NACHT, LRR and PYD domains-containing protein 3(NLRP3) may reflect differences in expression, secretion, turnover, or compartmentalization rather than a single mechanism. Interpretation is typically strengthened by evaluating related molecules (for example, phosphorylation-dependent signaling nodes, stress markers, and organelle proteins) and by keeping pre-analytical variables consistent across groups.
Nomenclature
In publications and databases, NACHT, LRR and PYD domains-containing protein 3(NLRP3) may also appear under names such as Nlrp3 and Cias1. When comparing studies, confirm that the reported analyte refers to the same molecule and species context.
Why ELISA data are widely used
ELISA is a common approach for quantitative measurement of proteins and biomarkers in complex samples, enabling comparisons across experimental groups and time points. When integrating results with other readouts, consider species biology, sample type, and the broader pathway context that NACHT, LRR and PYD domains-containing protein 3(NLRP3) participates in.
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Mesenchymal stem cells attenuate systemic lupus erythematosus by inhibiting NLRP3 inflammasome activation through Pim-1 kinase
H Yu,International immunopharmacology,2023
Qingre Huoxue Decoction regulates macrophage polarisation to attenuate atherosclerosis through the inhibition of NF-κB signalling-mediated inflammation
Z Jin,Journal of Ethnopharmacology,2022
Dose-dependent renoprotective impact of Lactoferrin against glycerol-induced rhabdomyolysis and acute kidney injury
AH Madkour,Life sciences,2022
NLRP3 inflammasome expression in lipopolysaccharide-induced otitis media
Kariya S, et al,Acta Oto-Laryngologica,2019
Systemic and Neuronal InflammatoryMarkers in a Mouse Model of Mevalonate Kinase Deficiency: a Strain-comparative Study
Kleiner G et al,In Vivo,2013
