| Field | Specification |
|---|---|
| Target | |
| Alternative names | Sdc1; Synd-1; Synd1; Syndecan-1; SYND1; CD antigen CD138 |
| UniProt # | |
| Species | |
| Reactivity | |
| Applications | |
| Assay type | |
| Sample type(s) | serum, plasma, tissue homogenates |
| Sensitivity | |
| Detection range | |
| Detection wavelength | |
| Assay time | |
| Catalog no. (Mfr.) | |
| Main SKU |
Background
Syndecan-1(SDC1) is a biological molecule commonly studied in signal transduction research. It is commonly used as a molecular readout in mechanistic and biomarker-focused studies.
UniProt: P18828
Biological context
Researchers often monitor Syndecan-1(SDC1) in serum, plasma, and tissue homogenates to better understand themes such as mechanistic biology studies, biomarker-focused profiling, and disease-model research. In many model systems, measured levels can shift with physiology, experimental perturbation, or disease-associated changes, making careful biological interpretation important.
Interpreting changes in measured levels
Depending on sample matrix and study design, increases or decreases in Syndecan-1(SDC1) may reflect differences in expression, secretion, turnover, or compartmentalization rather than a single mechanism. Interpretation is typically strengthened by evaluating related molecules (for example, complementary pathway markers and controls appropriate to the biological model) and by keeping pre-analytical variables consistent across groups.
Nomenclature
In publications and databases, Syndecan-1(SDC1) may also appear under names such as Sdc1 and Synd-1. When comparing studies, confirm that the reported analyte refers to the same molecule and species context.
Why ELISA data are widely used
ELISA is a common approach for quantitative measurement of proteins and biomarkers in complex samples, enabling comparisons across experimental groups and time points. When integrating results with other readouts, consider species biology, sample type, and the broader pathway context that Syndecan-1(SDC1) participates in.
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Neutrophil extracellular traps-induced pyroptosis of liver sinusoidal endothelial cells exacerbates intrahepatic coagulation in cholestatic mice
M Yu, C Zheng, X Li, X Ji, X Hu, X Wang,Biochimica et Biophysica Acta-Molecular Basis of Disease,2025
Analysis of the prognostic efficacy of syndecan-1 for patients with ACLF and its functional role in liver regeneration
Y He, X Zhang, Y Yao, J Li, S Fu,BMC medicine,2025
Lactylation of Histone H3k18 and Egr1 Promotes Endothelial Glycocalyx Degradation in Sepsis‐Induced Acute Lung Injury
Z Lu, P Fang, S Li, D Xia, J Zhang, X Wu,Advanced Science,2024
Neutrophil extracellular traps drive intestinal microvascular endothelial ferroptosis by impairing Fundc1-dependent mitophagy
C Chu,Redox biology,2023
Sedation with propofol and isoflurane differs in terms of microcirculatory parameters: A randomized animal study using dorsal skinfold chamber mouse model
S Guo,Microvascular research,2024
6% Hydroxyethyl starch (HES 130/0.4) diminishes glycocalyx degradation and decreases vascular permeability during systemic and pulmonary inflammation in mice
Margraf A.et al,Crit Care,2018
