MPX-004

Product details

• Chemical name: (5-(((3-chloro-4-fluoropheyl)sulfonamido)methyl)-N-((2-methylthiazol-5-yl)methyl)pyrazine-2-carboxamide).
• CAS number: 1688684-07-2
• Molecular formula: C17H15ClFN5O3S2.
• Purity: >99% (HPLC)
• Concentration: 0.1-10 µM.
• Form: Lyophilized powder.
• Solubility: DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
• Reconstitution: DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
• Shipping: Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
• Target: GluN2A-containing NMDA receptors
• Source: Synthetic
• Activity: A novel pyrazine-containing NMDA receptor antagonist, highly selective for NR2A-containing receptors (IC50 = 79 nM in HEK cells) over NR2B and NR2D1.

Scientific background

MPX-004 is a synthetic compound that acts as a potent and selective GluN2A-containing NMDA receptor antagonist with an IC50 value of 79 nM in HEK cells1.MPX-004 is a pyrazine-containing antagonist with optimal halogen substituents on the phenylsulfonamide aryl ring. It is used as a pharmacological tool for studying the physiology of NMDA receptors containing the GluN2A subunit1.NMDA receptors are heterotetramers composed by 2 GluN1 obligatory subunits and 2 GluN2 (A-D) or GluN3 (A-B) regulatory subunits. GluN2A is the most abundant subunit in the mammalian CNS. Physiological and genetic evidence show that GluN2A-containing receptors are involved in autism, schizophrenia, childhood epilepsy and neurodevelopmental disorders such as Rett Syndrome1,2.

Lead time: 1-2 Business Days

Country of origin: Israel/IL

Applications key

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

Bioassay tested: Yes

• SDS (PDF)

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