| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C26H35FN16O2 |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
MRL-494 is an antibacterial agent that inhibits β-barrel assembly machine A (BamA) and is unaffected by efflux and the outer membrane permeability barrier. It can inhibit Gram-positive bacteria, with an MIC of 12.5 μM for Staphylococcus aureus COL, and Gram-negative bacteria, with an MIC of 25 μM for E. coli JCM158[1]. It has the molecular formula C26H35FN16O2 (MW 622.66).
Physical & Chemical Properties
| CAS Number | 2434898-43-6 |
|---|---|
| Molecular Formula | C26H35FN16O2 |
| Molecular Weight | 622.66 g/mol |
| SMILES | FC1=CC=C(C2=NN(CC(N[C@@H]3CC[C@H](NC4=NC(NC(C5CC5)CC(NC(N)=N)=O)=NC(NC(N)=N)=N4)CC3)=O)N=N2)C=C1 |
| Signaling Pathway | Anti-infection |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
In Vitro
MRL-494 disrupts the cytoplasmic membrane in a lethal manner. By targeting BamA, MRL-494 inhibits the biogenesis of OM proteins (OMPs) from outside the outer membrane (OM). MRL-494 has strong anti-microbial activity against both Gram-positive and Gram-negative bacteria. Its MIC values are 25 μM against E. coli (WT), 25 μM against E. coli (ΔtolC), 25 μM against E. coli (ΔtolC envA101), 100 μM against K. pneumonia, 200 μM against A. baumannii (WT), 200 μM against A. baumannii (ΔlpxC), 100 μM against P. aeruginosa (efflux deficient), 100 μM against P. aeruginosa (WT), 12.5 μM against Staphylococcus aureus (methicillin-resistant), and 25 μM against Bacillus subtilis rpoB18[1].
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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Proc Natl Acad Sci U S A. 2026 May 20;123(21):e2536912123.
Mutations in the essential outer membrane protein BamA contribute to Escherichia coli resistance to the antimicrobial peptide TAT-RasGAP317-326. J Biol Chem 2025 Jan;301(1):108018. PMID: 39608713
