| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | 3-pyridinylmethyl [[4-[[(2-aminophenyl)amino]carbonyl]phenyl]methyl]carbamate, N-(2-Aminophenyl)-4-[N-(pyridine-3ylmethoxycarbonyl)aminomethyl]benzamide |
| Cas No. | |
| Form | Off white solid |
| Molecular Weight | |
| Product Type | |
| Purity | |
| Shipping | |
| SMILES | |
| Solubility | Soluble in DMSO or methanol. |
| Source | Synthetic |
| Storage |
MS 275 (Entinostat) is a selective inhibitor of class I histone deacetylases (HDACs), which regulate chromatin structure and gene expression. In neuroscience, MS 275 is used to study epigenetic mechanisms underlying neurodevelopment, synaptic plasticity, and neurodegeneration. HDAC inhibition by MS 275 promotes histone acetylation, leading to transcriptional activation of neuroprotective genes. It has shown promise in models of Alzheimer's and Huntington's disease by enhancing cognitive function and reducing neuroinflammation. MS 275 is a valuable tool for exploring epigenetic therapies aimed at restoring neuronal health and function.
Classification: D1B Toxic Material Causing Immediate and SeriousToxic Effects, Toxic by ingestion, D2A Very Toxic Material Causing Other Toxic Effects, Teratogen, D2B Toxic Material Causing Other Toxic Effects, Reproductive hazard, Moderate skin irritant, Moderate eye irritant
Safety Phrases:
- S22 - Do not breathe dust.
- S24/25 - Avoid contact with skin and eyes.
- S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
Hazard statements:
- H301 Toxic if swallowed.
- H315 Causes skin irritation.
- H319 Causes serious eye irritation.
- H335 May cause respiratory irritation.
- H360 May damage fertility or the unborn child.
Precautionary statements:
- P201 Obtain special instructions before use.
- P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray.
- P301 + P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/ physician.
- P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
- P308 + P313 IF exposed or concerned: Get medical advice/ attention.
MS-275 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-416)
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).
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