| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Source | Plant — Rutaceae Murraya koenigii (L.) Spreng |
| Molecular weight | |
| Molecular formula | C24H29NO2 |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
Murrayanol is a natural carbazole alkaloid with a variety of biological activities, showing anti-inflammatory activity and inhibiting both topoisomerase I and topoisomerase II. It also acts as a mosquitocidal and antimicrobial agent[1]. It has a molecular formula of C24H29NO2 and a molecular weight of 363.49 g/mol.
Physical & Chemical Properties
| CAS Number | 144525-81-5 |
|---|---|
| Molecular Formula | C24H29NO2 |
| Molecular Weight | 363.49 g/mol |
| Structure Classification | Alkaloids Indole Alkaloids |
| SMILES | OC1=C(C/C=C(C)/CC/C=C(C)\C)C(NC2=C3C=C(C)C(OC)=C2)=C3C=C1 |
| Signaling Pathway | Cell Cycle/DNA Damage; Anti-infection |
| Initial Source | Plant — Rutaceae Murraya koenigii (L.) Spreng |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
In Vitro
In anti-inflammatory assays, Murrayanol has an IC50 of 109 μg/mL against hPGHS-1 (human prostaglandin H synthase isozyme 1), and an IC50 of 218 μg/mL against hPGHS-2[1]. At 12.5 μg/mL, Murrayanol causes 100% mortality in Aedes aegyptii[1]. When tested on S. cerevisiae mutant strains, Murrayanol fully inhibits topoisomerase I and II activity at 50 μg/mL[1]. Murrayanol gives an MIC100 of 100 μg/mL against C. kruseii and E. coli, and an MIC100 of 25 μg/mL against S. aureus and S. pyogenes[1].
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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