| Field | Specification |
|---|---|
| Alternative names | (+)-Muscarine tosylate |
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C16H27NO5S |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
Muscarine tosylate, also known as (+)-Muscarine tosylate, is an agonist of the prototype mAChR. As a toxin, it can stimulate the parasympathetic nervous system[1][2]. It has a molecular formula of C16H27NO5S and a molecular weight of 345.45 g/mol.
Physical & Chemical Properties
| CAS Number | 82083-43-0 |
|---|---|
| Molecular Formula | C16H27NO5S |
| Molecular Weight | 345.45 g/mol |
| SMILES | C[N+](C)(C)C[C@@H]1C[C@H]([C@@H](O1)C)O.O=S([O-])(C2=CC=C(C=C2)C)=O |
| Signaling Pathway | GPCR/G Protein; Neuronal Signaling |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
In Vitro
In brain micro vascular endothelial cells (BMVECs) and in Endothelial cells.3 (bEnd.3) of brain origin, Muscarine tosylate (100 μM) induces an intracellular calcium signal of an amplitude similar to that triggered by 10 μM acetylcholine[1]. In a sub-population of cells in the nucleus raphe magnus (NRM) that contain 5-hydroxytryptamine (5-HT), Muscarine tosylate (1-30 μM; 2 min) produces a dose-dependent hyperpolarization on the NRM neurons, with an EC50 value of 2.7 μM[2].
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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Long-range cholinergic input promotes glioblastoma progression. Cancer Cell 2025 Nov 10;43(11):2089-2105.e10. PMID: 40829591
