| Field | Specification |
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| Mfr No | |
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| Host | |
| Immunogen | A synthesized peptide derived from human MYH2 was used as the immunogen for the MYH2 antibody. |
| Isotype | |
| Product Type | |
| Purity | |
| Reactivity | |
| Storage | |
| Target | |
| UniProt # |
Overview
MYH2 Antibody / Myosin heavy chain 2 is a anti-MYH2 Rabbit antibody Recombinant Rabbit Monoclonal clone 32M67 supplied in Liquid format. Recommended for workflows such as Western blot (WB) with listed reactivity in Human, Mouse, Rat.
Key elements and design rationale
- Target: MYH2
- Antibody details: Rabbit, Recombinant Rabbit Monoclonal, clone 32M67, isotype Rabbit IgG
- Format: Liquid
- Applications (as listed): WB
Biological background
MYH2 antibody is widely applied in muscle physiology, pathology, and developmental biology research. Detection of MYH2 expression distinguishes type IIa fibers from other fiber types, supporting studies of muscle composition and plasticity. In clinical research, MYH2 expression patterns are examined in muscular dystrophy, myopathies, and age-related sarcopenia. By detecting MYH2, researchers can assess muscle adaptation to exercise, disease, and therapeutic interventions.
Western blot assays detect MYH2 protein in skeletal muscle extracts. Immunohistochemistry maps MYH2 distribution within muscle cross sections, enabling identification of fiber type composition. Immunofluorescence highlights sarcomeric localization, providing high-resolution visualization of contractile architecture.
MYH2 mutations cause autosomal dominant myopathy characterized by progressive muscle weakness, abnormal fiber morphology, and impaired contractility. Detection with MYH2 antibody supports genetic and pathological studies of this disease. Additionally, MYH2 is a marker of regenerative fibers and is used to study developmental myogenesis. By applying MYH2 antibody, scientists can investigate both physiological and pathological aspects of skeletal muscle biology.
Beyond skeletal muscle, MYH2 research contributes to understanding of biomechanics, metabolic regulation, and aging. Differences in MYH2 expression across individuals and conditions reflect muscle plasticity and adaptation. The antibody therefore provides a critical reagent for both basic science and translational studies in muscle biology.
MYH2 antibody from
Research relevance and current trends
- Connecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).
- Considering isoforms and post-translational regulation when interpreting protein-level changes.
- Comparing results across species and model systems with matched controls.
Common research applications
- Western blotting: compare relative abundance and activation-state changes across conditions.
Interpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.
Notes for experimental interpretation
- Signal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.
- Species differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.
Antibody notes: Monoclonal antibodies provide a defined epitope recognition profile that can support consistent comparisons across experiments.
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
