| Field | Specification |
|---|---|
| Applications | |
| Molecular weight | |
| Molecular formula | C60H81ClFN11O15 |
| Activity | |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
N3-PEG8-Phe-Lys-PABC-Gefitinib is an agent-linker conjugate for ADCs with potent antitumor activity, formed by linking the antitumor agent Gefitinib (an orally active EGFR tyrosine kinase inhibitor) via the cleavable linker N3-PEG8-Phe-Lys-PABC. It is also a click chemistry reagent: its azide group can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules bearing alkyne groups, and it can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups. It has the molecular formula C60H81ClFN11O15 and a molecular weight of 1250.80 g/mol.
Physical & Chemical Properties
| Molecular Formula | C60H81ClFN11O15 |
|---|---|
| Molecular Weight | 1250.80 g/mol |
| SMILES | ClC1=C(C=CC(NC2=NC=NC3=C2C=C(C(OC)=C3)OCCCNC(OCC4=CC=C(NC([C@H](CCCCN)NC([C@@H](NC(CCOCCOCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-])=O)CC5=CC=CC=C5)=O)=O)C=C4)=O)=C1)F |
| Signaling Pathway | Antibody-Drug Conjugate/ADC Related; Protein Tyrosine Kinase/RTK; JAK/STAT Signaling |
| Bioactivity Class | Traditional Cytotoxic Agents |
| Solubility | In Vitro: DMSO: 50 mg/mL (39.97 mM; Requires sonication; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
In Vitro
| Solvent | Solubility | Notes |
|---|---|---|
| DMSO | 50 mg/mL (39.97 mM) | requires sonication; use freshly opened DMSO (absorbed moisture lowers solubility) |
Data provided by the manufacturer.
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