N6-Methyl-dA phosphoramidite

SKU:BHB21901068
Overview
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N6-Methyl-dA phosphoramidite (CAS 105931-58-6) is a nucleoside/nucleotide analog supplied as a solid. Relevant to Cell Cycle/DNA Damage research. Molecular formula C41H50N7O6P, molecular weight 767.85 g/mol.
Purity 99.83%
CAS Number 105931-58-6
Molecular Weight 767.85 g/mol
Form Solid
Storage 4°C as supplied; in solvent -80°C
Options selector
Catalog no. Size
HY-138582-25MG 25 mg
HY-138582-50MG 50 mg
HY-138582-100MG 100 mg
HY-138582-200MG 200 mg
HY-138582-500MG 500 mg
Available Options

Select the variant that best fits your experiment. Availability and lead time may vary by option.

  • Options: Size: 25 mg, 50 mg, 100 mg, 200 mg, 500 mg
  • Lead time: varies by selected option.
  • Storage: 4°C, sealed storage, away from moisture and light. In solvent: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light).
  • Shipping: Room temperature in continental US; may vary elsewhere.
  • Upon receipt: refrigerate at 4°C as soon as possible.
Field Specification
CAS no. 105931-58-6
Applications
  • Functional Assay (In Vitro)
Molecular weight 767.85
Molecular formula C41H50N7O6P
Purity 99.83%
SMILES COC1=CC=C(C(C2=CC=C(OC)C=C2)(OC[C@@H]3[C@@H](OP(N(C(C)C)C(C)C)OCCC#N)C[C@H](N4C(N=CN=C5NC)=C5N=C4)O3)C6=CC=CC=C6)C=C1
Form Solid
Storage 4°C, sealed storage, away from moisture and light. In solvent: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light).
Shipping Room temperature in continental US; may vary elsewhere.
Catalog no. (Mfr.) HY-138582
Main SKU BHB21901068
Nucleoside & Nucleotide Analogs

Compound Overview

N6-Methyl-dA phosphoramidite can be used in the synthesis of oligodeoxyribonucleotides[1]. It is supplied as a white to off-white solid (C41H50N7O6P, MW 767.85) at 99.83% purity.

Physical & Chemical Properties

CAS Number 105931-58-6
Molecular Formula C41H50N7O6P
Molecular Weight 767.85 g/mol
Purity 99.83%
Appearance Solid
Color White to off-white
SMILES COC1=CC=C(C(C2=CC=C(OC)C=C2)(OC[C@@H]3[C@@H](OP(N(C(C)C)C(C)C)OCCC#N)C[C@H](N4C(N=CN=C5NC)=C5N=C4)O3)C6=CC=CC=C6)C=C1
Signaling Pathway Cell Cycle/DNA Damage
Solubility In Vitro: DMSO: 250 mg/mL (325.58 mM; Requires sonication; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Storage 4°C, sealed storage, away from moisture and light. In solvent: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light).
Shipping Room temperature in continental US; may vary elsewhere.

Literature Cited

Sources cited in this description. Peer-reviewed publications that used this product are listed under References.

[1]. Li D, et al. Exocyclic carbons adjacent to the N6 of adenine are targets for oxidation by the Escherichia coli adaptive response protein AlkB. J Am Chem Soc. 2012 May 30;134(21):8896-901.

Safety

For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.

In Vitro

SolventSolubilityNotes
DMSO250 mg/mL (325.58 mM)requires sonication; use freshly opened DMSO (absorbed moisture lowers solubility)

Aliquot the stock solution and store it at -80°C (up to 6 months) or -20°C (up to 1 month); sealed storage, away from moisture and light; avoid repeated freeze-thaw cycles.

Data provided by the manufacturer.

Q.Why is there no price on some sizes?
A.Availability and lead time for those sizes are confirmed on inquiry. Send us the size you need and we will come back with price and lead time.
Q.Can this be used in humans or for diagnostics?
A.No. This product is supplied For Research Use Only. It is not for diagnostic or therapeutic procedures and not for human or veterinary use.

Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.

  • Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
  • Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
  • Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
  • QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
  • Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity

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