| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C13H8Cl2N2OS |
| Purity | |
| SMILES | |
| Form | Solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
N6F11 is a selective ferroptosis inducer that can trigger ferroptosis in cancer cells through TRIM25-mediated GPX4 degradation while sparing immune cells. It also initiates HMGB1-dependent antitumor immunity mediated by CD8+ T cells[1][2][3][4]. It is supplied as an off-white to light yellow solid (C13H8Cl2N2OS, MW 311.19) at 98.08% purity.
Physical & Chemical Properties
| CAS Number | 851398-76-0 |
|---|---|
| Molecular Formula | C13H8Cl2N2OS |
| Molecular Weight | 311.19 g/mol |
| Purity | 98.08% |
| Appearance | Solid |
| Color | Off-white to light yellow |
| SMILES | ClC1=CC=C(C2=CC3=C(C(NC(CCl)=N3)=O)S2)C=C1 |
| Signaling Pathway | Apoptosis |
| Solubility | In Vitro: DMSO: 31.25 mg/mL (100.42 mM; Requires sonication and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) |
| Storage | 4°C, protect from light. In solvent: -80°C, 6 months; -20°C, 1 month (protect from light). |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.
In Vitro
| Solvent | Solubility | Notes |
|---|---|---|
| DMSO | 31.25 mg/mL (100.42 mM) | requires sonication and warming and heat to 60°C; use freshly opened DMSO (absorbed moisture lowers solubility) |
Aliquot the stock solution and store it at -80°C (up to 6 months) or -20°C (up to 1 month); protect from light; avoid repeated freeze-thaw cycles.
Data provided by the manufacturer.
In Vitro
N6F11 (5 μM, 12 h) lowers GPX4 expression by enhancing protein degradation rather than by reducing gene transcription, and induces autophagy-independent ferroptosis in PANC1 cells[1].
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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Exploiting dysregulated iron homeostasis to eradicate persistent high-grade serous ovarian cancer. Cell Death Discov 2025 Sep 25;11(1):423. PMID: 40998801
