| Field | Specification |
|---|---|
| Target | |
| Alternative names | ATP1A1; Sodium/potassium-transporting ATPase subunit alpha-1; Na(+)/K(+) ATPase alpha-1 subunit; Sodium pump subunit alpha-1 |
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| Applications | |
| Immunogen | Synthesized peptide derived from human Na+/K+-ATPase α1 around the non-phosphorylation site of S16 |
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Background
Sodium/potassium-transporting ATPase subunit alpha-1 encoded by ATP1A1 belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 1 subunit. Multiple transcript variants encoding different isoforms have been found for this gene.
Others
Na+/K+-ATPase α1 Polyclonal Antibody detects endogenous levels of Na+/K+-ATPase α1 protein.
Elucidating the role of N-myristoylation in the excessive membrane localization of PD-L1 in hypoxic cancers and developing a novel NMT1 inhibitor for combination with immune checkpoint blockade therapy.(ABL1141-12.800)
Author: Zhao, Haoming, et al., Publication name: Journal of Experimental & Clinical Cancer Research, IF: 12.800
Ce6 derivative photodynamic therapy triggers PANoptosis and enhances antitumor immunity with LAG3 blockade in cutaneous squamous cell carcinoma.(ABL1141-10.600)
Author: Chen, Diyan, et al., Publication name: Cell Reports Medicine, IF: 10.600
Carvedilol inhibits neuronal hyperexcitability caused by epilepsy‐associated KCNT1 mutations.(ABL1141-7.700)
Author: Di, Chang, et al., Publication name: British Journal of Pharmacology, IF: 7.700
SUMO1 modification of IGF-1R combining with SNAI2 inhibited osteogenic differentiation of PDLSCs stimulated by high glucose(ABL1141-5.116)
Author: Jiang R, Wang M, Shen X, Huang S, Han J, Li L, Xu Z, Jiang C, Zhou Q, Feng X,, Publication name: Stem Cell Res Ther, IF: 5.116
Graphene oxide disrupted mitochondrial homeostasis through inducing intracellular redox deviation and autophagy-lysosomal network dysfunction in SH(ABL1141-4.5)
Author: F Xiaoli, Z Yaqing, L Ruhui, L Xuan, C Aijie, Publication name: Journal of Hazardous, IF: 4.5
