| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C12H17N3O6 |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
Nagstatin is a naturally derived, competitive inhibitor of N-acetyl-β-D-glucosaminidase (NAG-ase), with an IC50 of 0.0012 μg/mL and a Ki of 1.7×10-8 M against the porcine-derived enzyme. It enhances cellular immune responses in normal mice, reactivates suppressed cellular immune responses in tumor-bearing mice, and can be used in research on diseases such as diabetes and leukemia[1]. Its molecular formula is C12H17N3O6, with a molecular weight of 299.28 g/mol.
Physical & Chemical Properties
| CAS Number | 126844-81-3 |
|---|---|
| Molecular Formula | C12H17N3O6 |
| Molecular Weight | 299.28 g/mol |
| SMILES | N(C(C)=O)[C@H]1C=2N([C@H](CO)[C@H](O)[C@@H]1O)C=C(CC(O)=O)N2 |
| Signaling Pathway | Metabolic Enzyme/Protease |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
In Vitro
Partially purified porcine kidney N-acetyl-β-D-glucosaminidase is inhibited by Nagstatin potently, specifically and competitively, (IC50 of 0.0012 μg/mL; Ki of 1.7×10-8 M)[1]. Nagstatin inhibits N-acetyl-β-D-glucosaminidase from several sources: Spodoptera litura (IC50 5.85 nM; Ki 1.10 nM), Aspergillus oryzae (IC50 10.6 nM; Ki 9.69 nM), Penicillium oxalicum (IC50 60.6 nM; Ki 8.11 nM), human placenta (IC50 1.83 nM; Ki 0.952 nM), bovine kidney (IC50 1.71 nM; Ki 1.64 nM), and jack bean (IC50 1.87 nM; Ki 1.41 nM)[2].
In Vivo
Nagstatin (250 mg/kg; i.p.; single dose) shows low acute toxicity in mice, with no mortality at a single intraperitoneal dose of 250 mg/kg[1]. In normal mice, Nagstatin potentiates the cellular immune response at a potency comparable to bestatin[1]. In tumor-bearing mice, Nagstatin reactivates a depressed cellular immune response at a potency comparable to bestatin[1].
| Animal Model | Mice[1] |
|---|---|
| Dosage | 250 mg/kg |
| Administration | i.p.; single dose |
| Result | Observed no deaths. |
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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