| Field | Specification |
|---|---|
| Mfr No | |
| Accession Number | |
| Alternative Names | Nav1.7, SCN9A, ETHA, hNE Na, NE NA, PN1, Voltage gated sodium channel subunit alpha Nav1, Peripheral sodium channel 1, Neuroendocrine sodium channel |
| Cellular Localization | |
| Clonality | |
| Concentration | |
| Host | |
| Immunogen | Fusion protein amino acids 1751-1946 (C-terminus) of human Nav1.7 |
| Isotype | |
| Product Type | |
| Reactivity | |
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| Target |
Nav1.7 is a voltage-gated sodium channel encoded by the SCN9A gene and is predominantly expressed in peripheral sensory neurons. It plays a pivotal role in pain perception by amplifying subthreshold stimuli and facilitating action potential initiation.
Loss-of-function mutations in Nav1.7 result in congenital insensitivity to pain, while gain-of-function mutations are associated with chronic pain syndromes. Importantly, Nav1.7 is not expressed in cardiac or central neurons, making it an attractive target for pain therapeutics with minimal off-target effects.
Although primarily studied in nociception, emerging research suggests that peripheral nerve dysfunction and chronic pain may contribute to neurodegenerative disease burden. Nav1.7 inhibitors are under investigation as next-generation analgesics with potential applications in neurodegenerative conditions involving neuropathic pain.
1 µg/ml of SMC-314 was sufficient for detection of Nav1.7 in 10 µg of HEK-293 cell lysate transiently expressing Nav1.7 by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Cite this product varies by variant:
- SMC-314D — Size: 100 ug: Nav1.7 Antibody (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-314D, RRID: AB_2254237)
- SMC-314D-A390 — Size: 100 ug: Nav1.7 Antibody: ATTO 390 (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-314D-A390, RRID: AB_2700244)
- SMC-314D-A488 — Size: 100 ug: Nav1.7 Antibody: ATTO 488 (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-314D-A488, RRID: AB_2700245)
- SMC-314D-A594 — Size: 100 ug: Nav1.7 Antibody: ATTO 594 (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-314D-A594, RRID: AB_2700247)
- SMC-314D-APC — Size: 100 ug: Nav1.7 Antibody: APC (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-314D-APC, RRID: AB_2700253)
- SMC-314D-BI — Size: 100 ug: Nav1.7 Antibody: Biotin (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-314D-BI, RRID: AB_2700254)
- SMC-314D-FITC — Size: 100 ug: Nav1.7 Antibody: FITC (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-314D-FITC, RRID: AB_2700255)
- SMC-314D-HRP — Size: 100 ug: Nav1.7 Antibody: HRP (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-314D-HRP, RRID: AB_2700256)
- SMC-314D-PCP — Size: 100 ug: Nav1.7 Antibody: PerCP (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-314D-PCP, RRID: AB_2700258)
- SMC-314D-RPE — Size: 100 ug: Nav1.7 Antibody: RPE (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-314D-RPE, RRID: AB_2700259)
- SMC-314S — Size: 12 ug: Nav1.7 Antibody (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-314S, RRID: AB_2254237)
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
2. Dray A., Read S.J (2007) Arthritis Res. Ther. 9(3): 212.
3. Samuels M.E., teMorshe R.H., Lynch M.E., Drenth J.P. (2008) Mol Pain. 4: 21.
