| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Cas No. | |
| Concentration | |
| Form | Lyophilized Powder |
| Product Type | |
| Purity | |
| Reconstitution | |
| Shipping | |
| Solubility | Soluble up to 200 mM in DMSO. Centrifuge all products before handling (10000 x g 5 min). |
| Source | Synthetic |
| Storage | |
| Target |
Product details
- Chemical name: 4-(5-Chloro-6-(2,5-difluorophenoxy)-3-pyridinyl)-2-fluoro-5-methoxy-N-(methylsulfonyl)benzamide.
- Also known as: 4-(5-Chloro-6-(2,5-difluorophenoxy)-3-pyridinyl)-2-fluoro-5-methoxy-N-(methylsulfonyl)benzamide
- CAS number: 1694633-51-6
- Molecular formula: C20H14ClF3N2O5S.
- Purity: >99% (HPLC)
- Concentration: 50 nM - 50 µM.
- Form: Lyophilized Powder
- Solubility: Soluble up to 200 mM in DMSO. Centrifuge all products before handling (10000 x g 5 min).
- Reconstitution: Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in sterile water at a concentration of at least 0.1 mg/mL. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. It is recommended to prepare fresh solutions in working buffers just before use. For long-term storage of diluted solutions, we recommend adding 0.1% BSA. Repeat freeze-thawing may result in loss of activity.
- Shipping: Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
- Target: NaV1.7 channels
- Source: Synthetic
- Activity: NaV1.7-Compound 36 is a potent and selective blocker of NaV1.7 channels. It inhibits human NaV1.7 with IC50 of 69 nM. Compound 36 is selective for NaV1.7 over other human NaV isoforms and important targets, such as hERG1.
- Alternative names: 4-(5-Chloro-6-(2,5-difluorophenoxy)-3-pyridinyl)-2-fluoro-5-methoxy-N-(methylsulfonyl)benzamide
Scientific background
NaV1.7-Compound 36 is a potent and selective blocker of NaV1.7 channels. NaV1.7-Compound 36 inhibits human NaV1.7 channels with IC50 value of 69 nM1.There are nine mammalian subtypes of NaV channels: NaV1.1-NaV1.9. They are essential for the initiation of action potentials in excitable cells and are considered to be important therapeutic targets for numerous pathophysiological conditions such as cardiac arrhythmia, and epilepsy. NaV1.7 channel plays an important role in nociception and it is an important therapeutic target in chronic pain1,2.
Lead time: 1-2 Business Days
Country of origin: Israel/IL
Applications key
Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.
Bioassay tested: Yes
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- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
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