NBQX

Product details

• Chemical name: 2,3-Dioxo-6-nitro-1,2,3,4-tetrahydrobenzo[f]quinoxaline-7-sulfonamide.
• CAS number: 118876-58-7
• Molecular formula: C12H8N4O6S.
• Purity: >99%
• Concentration: 0.1-500 µM.
• Form: Lyophilized powder.
• Solubility: DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
• Reconstitution: DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
• Shipping: Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
• Target: AMPA/Kainate receptors
• Source: Synthetic
• Activity: NBQX is a potent inhibitor of non-NMDA glutamate receptor channels exhibiting IC50s of 0.1-0.4 μM for AMPA and 1.7-8 μM for kainate receptors1.

Scientific background

The α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPA receptor) is a non-N-methyl-D-aspartate (non-NMDA) type ionotropic transmembrane receptor for glutamate that mediates fast synaptic transmission in the central nervous system (CNS)1. AMPA receptors normally assemble from four genetically distinct subunits: GluR1, GluR2, GluR3, and GluR4, which combine to form receptor complexes with different functional properties2.NBQX (2,3-Dihydroxy-6-nitro-7-sulfamoyl-benzo(F) quinoxaline) is an analogue of the quinoxalinedione antagonists to the non-NMDA glutamate receptor. NBQX is a potent and selective inhibitor of binding to the quisqualate subtype of the glutamate receptor, with no activity at the NMDA and glycine site3. It is a specific and potent AMPA receptor antagonist and has been found to be neuroprotective in various models of ischemia and to have anticonvulsant properties in different models of epilepsy4. NBQX has been reported to block the excitatory actions of AMPA in rat neocortex slices while having no effect on NMDA responses5. It was also reported to selectively block AMPA-induced depolarizations but not spontaneous epileptiform discharges in Mg2+ free medium in the rat cortical wedge6. NBQX blocks AMPA and kainate receptors at micromolar concentrations7,8.

Lead time: 1-2 Business Days

Country of origin: Israel/IL

Applications key

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

Bioassay tested: Yes

• SDS (PDF)

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