| Field | Specification |
|---|---|
| Applications | |
| Molecular weight | |
| Molecular formula | C31H35F3N2O5S |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
NDNA4 is a selective inhibitor of Hsp90α, with an IC50 of 0.34 μM. As a permanently charged analog it shows low membrane permeability and low cytotoxicity toward Ovcar-8 and MCF-10A cells (IC50 >100 μM), and it prevents disruption of hERG channel maturation without triggering a heat shock response or degrading Hsp90α-dependent client proteins[1]. It has the molecular formula C31H35F3N2O5S and a molecular weight of 604.68 g/mol.
Physical & Chemical Properties
| Molecular Formula | C31H35F3N2O5S |
|---|---|
| Molecular Weight | 604.68 g/mol |
| SMILES | C[N+](C)(C)CCCOC1=CC2=C(CN(C(C3=CC=C(O)C(SC4=CC=C(C)C(C)=C4)=C3)=O)C2)C=C1.O=C([O-])C(F)(F)F |
| Signaling Pathway | Cell Cycle/DNA Damage; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Biological Activity
IC50 & Target
IC50: 0.34 μM (Hsp90α)[1]
Literature Cited
Sources cited in this description. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
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