| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | (3S,4aS,8aS)-N-(1,1-Dimethylethyl)decahydro-2-[(2R,3R)-2-hydroxy-3-[(3-hydroxy-2-methylbenzoyl)amino]-4-(phenylthio)butyl]-3-isoquinolinecarboxamide methanesulfonate; AG-1343 |
| Cas No. | |
| Form | White powder |
| Molecular Weight | |
| Product Type | |
| Purity | |
| Shipping | |
| SMILES | |
| Solubility | May be dissolved in DMSO (70 mg/ml) |
| Source | Synthetic |
| Storage |
Nelfinavir mesylate, originally developed as an HIV protease inhibitor, has gained attention for its broader biological effects, including autophagy induction and anti-cancer activity. It modulates the Akt/PKB signaling pathway and triggers endoplasmic reticulum stress, leading to activation of the unfolded protein response.
These mechanisms are increasingly relevant in neurodegenerative disease research, where protein misfolding, ER stress, and impaired autophagy are central features. Nelfinavir’s ability to influence these pathways positions it as a potential candidate for repurposing in neurodegenerative disorders such as Alzheimer’s and Parkinson’s disease.
Hazard Statement:
H413 May cause long lasting harmful effects to aquatic life.
Nelfinavir mesylate (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-586)
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
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