| Field | Specification |
|---|---|
| Applications | |
| Molecular weight | |
| Molecular formula | C30H26N6O5S |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
NF-κB-IN-12 is a potent NF-κB inhibitor, with an IC50 of 1.02 μM, and it can be used in acute lung injury research[1]. It has the molecular formula C30H26N6O5S and a molecular weight of 582.63 g/mol.
Physical & Chemical Properties
| Molecular Formula | C30H26N6O5S |
|---|---|
| Molecular Weight | 582.63 g/mol |
| SMILES | O=C(N1N=CC(C2=CC=C(S(=O)(C3=CC=C(O)C=C3)=O)C=C2)C1C4=CC=C(OC)C=C4)C5=CN6C(C(NC)=NC=C6)=N5 |
| Signaling Pathway | NF-κB |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Biological Activity
IC50 & Target
IC50: 1.02 ± 0.29 μM (NF-κB)[1]
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
In Vitro
NF-κB-IN-12 shows no toxicity toward MCF-12A cells (normal epithelial cells)[1].
In Vivo
In SD rats, NF-κB-IN-12 (5-10 mg/kg, IP, daily) offers a protective effect against sepsis induced by the CLP (cecal ligation puncture) method[1].
| Animal Model | Sprague-Dawley (SD) rats (male, 7-9 weeks old, weighing 210-260 g)[1] |
|---|---|
| Dosage | 5, 10 mg/kg |
| Administration | IP, daily for 3 days before CLP surgery and on the 4th day 1 h before CLP |
| Result | Significantly upregulated SOD and GSH. Improved the antioxidant status of experimental rats. Reduced the elevated level of nuclear NF-ĸB. Caused a significant reduction in lung edema and total proteins, mononuclear leukocytes, and polymorphonuclear leukocytes in BALF (bronchoalveolar lavage fluid). |
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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