| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C62H50N4O4S |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
NF-κB-IN-9 is a nuclear factor kappa B (NF-κB)-targeting sonosensitizer, with excitation/emission maxima of 489/628 nm. Its two resveratrol units confer strong inhibition of NF-κB signaling. The compound shows anti-tumor activity with notable sonocytotoxicity against cancer cells, and has demonstrated biosafety in a xenograft mouse model. It has a molecular formula of C62H50N4O4S and a molecular weight of 947.15 g/mol.
Physical & Chemical Properties
| CAS Number | 3033815-24-3 |
|---|---|
| Molecular Formula | C62H50N4O4S |
| Molecular Weight | 947.15 g/mol |
| SMILES | COC1=CC(OC)=CC(/C=C/C2=CC=C(C=C2)N(C3=CC=CC=C3)C4=CC=C(C=C4)C5=CC=C(C6=NSN=C65)C7=CC=C(C=C7)N(C8=CC=CC=C8)C9=CC=C(C=C9)/C=C/C%10=CC(OC)=CC(OC)=C%10)=C1 |
| Signaling Pathway | NF-κB |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
In Vitro
In RAW 264.7 macrophages, NF-κB-IN-9 (TR2) (1 nM-10 μM) inhibits NO production with an EC50 value of 68.9 nm[1]. In MCF-7 cells, NF-κB-IN-9 (10 μM; 30 s ultrasonic treatment) inhibits proliferation and induces apoptosis. NF-κB-IN-9 is sonocytotoxic to MCF-7 cells, with IC50s of 1.6 μM, 0.55 μM, 0.29 μM at ultrasonic treatment times of 30 s, 2 min, 5 min, respectively[1].
In Vivo
In xenograft mouse models, NF-κB-IN-9 (TR2) given at 1.5 mg/kg (iv; at day 0 and 10, respectively) displays anticancer efficacy together with good tolerance. Fluorescence from NF-κB-IN-9 can be detected in the brain, suggesting that TR2 could penetrate the blood-brain barrier[1].
| Animal Model | MCF-7 xenograft mouse model[1] |
|---|---|
| Dosage | 1.5 mg/kg |
| Administration | Intravenous injection at day 0 and 10, respectively |
| Result | Inhibited tumor growth with no significant decrease in body weight. Decreased the cytokine levels in the sera of mice by 42%, indicating TR2 induced an anti-inflammatory response. |
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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