| Field | Specification |
|---|---|
| Target | |
| Applications | |
| Molecular weight | |
| Molecular formula | C26H24ClN3O6 |
| Purity | |
| SMILES | |
| Form | Solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT hydrochloride (Formula I) is an inhibitor of topoisomerase I (TOP1). It is applicable to the synthesis of the antibody-drug conjugate ABBV-969 and has been used in research on lung adenocarcinoma and melanoma[1]. It is supplied as a yellow to brown solid (C26H24ClN3O6, MW 509.94) at 98.46% purity.
Physical & Chemical Properties
| Molecular Formula | C26H24ClN3O6 |
|---|---|
| Molecular Weight | 509.94 g/mol |
| Purity | 98.46% |
| Appearance | Solid |
| Color | Yellow to brown |
| SMILES | NC12CC(C2)(C3=C4C(C(N5C4)=CC([C@](O)(C(OC6)=O)CC)=C6C5=O)=NC7=CC(OCO8)=C8C=C73)C1.[H]Cl |
| Target | Topoisomerase I |
| Signaling Pathway | Antibody-Drug Conjugate/ADC Related; Cell Cycle/DNA Damage |
| Solubility | In Vitro: DMSO: 25 mg/mL (49.03 mM; Requires sonication and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) |
| Storage | 4°C, sealed storage, away from moisture and light. In solvent: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
[1]. Andrew C. Phillips, et al. Anti-c-met antibody drug conjugates.WO2022232834.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.
In Vitro
| Solvent | Solubility | Notes |
|---|---|---|
| DMSO | 25 mg/mL (49.03 mM) | requires sonication and warming and heat to 60°C; use freshly opened DMSO (absorbed moisture lowers solubility) |
Aliquot the stock solution and store it at -80°C (up to 6 months) or -20°C (up to 1 month); sealed storage, away from moisture and light; avoid repeated freeze-thaw cycles.
Data provided by the manufacturer.
In Vitro
(7S)-14-(3-aminobicyclo[1.1.1]pentan-1-yl)-7-ethyl-7-hydroxy-2H,10H-[1,3]dioxolo[4,5-g]pyrano[3',4':6,7]indolizino[1,2-b]quinoline-8,11(7H,13H)-dione potently reduces the viability of Calu-6 (human lung adenocarcinoma) and A375 (human malignant melanoma) cells, where the EC50 values are 0.57 nM and 0.50 nM, respectively[1].
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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