| Field | Specification |
|---|---|
| Target | |
| Alternative names | (±)-Nitidanin |
| CAS no. | |
| Applications | |
| Source | Plant — Buxaceae Buxus microphylla S.et Z.var. Sinica Rehd.et Wils. |
| Molecular weight | |
| Molecular formula | C21H24O8 |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
Nitidanin, also known as (±)-Nitidanin, is an antimalarial and antiviral compound that can be isolated from the wood of Xanthoxylum nitidun D. C., showing IC50 values of 21.2 μM and 18.4 μM against the D6 and W2 clones of Plasmodium falciparum, respectively. It can be used in research on malaria and viral infection[1][2]. It has the molecular formula C21H24O8 and a molecular weight of 404.41 g/mol.
Physical & Chemical Properties
| CAS Number | 171674-89-8 |
|---|---|
| Molecular Formula | C21H24O8 |
| Molecular Weight | 404.41 g/mol |
| Structure Classification | Phenylpropanoids Lignans |
| SMILES | OC[C@@H]1OC2=C(OC)C=C(/C=C/CO)C=C2O[C@H]1C3=CC(OC)=C(O)C(OC)=C3 |
| Target | Plasmodium |
| Signaling Pathway | Anti-infection |
| Initial Source | Plant — Buxaceae Buxus microphylla S.et Z.var. Sinica Rehd.et Wils. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
[1]. Ma C, et al. Antimalarial compounds from Grewia bilamellata. J Nat Prod. 2006 Mar;69(3):346-50.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
In Vitro
Nitidanin is inhibitory against the D6 and W2 clones of Plasmodium falciparum, with IC50 values of 21.2 and 18.4 μM, respectively[1]. In human oral epidermoid carcinoma (KB) cells, Nitidanin is noncytotoxic, with an EC50 value >99 μM[1]. Nitidanin has a low cytotoxic effect on human hepatoma Huh7.5.1 cells, with a CC50 value of 464.4 μM[2]. At 0-250 μM for 5 hours, Nitidanin displays anti-HCV activity, with an IC50 value of 200 μM[2].
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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