| Field | Specification |
|---|---|
| Target | |
| Alternative names | Nitrotyrosine, Nitro tyrosine, 3-Nitrotyrosine |
| Host | |
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| Clonality | |
| Isotype | |
| Reactivity | |
| Applications | |
| Immunogen | 3-(4-hydroxy-3-nitrophenylacetamido) propionic acid-bovine serum albumin |
| Purification | |
| Concentration | |
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| Catalog no. (Mfr.) | |
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Nitrotyrosine is a post-translational modification formed by the nitration of tyrosine residues, often mediated by reactive nitrogen species such as peroxynitrite. It serves as a biomarker of nitrosative stress and is increasingly recognized for its role in neurodegenerative disease pathology. Nitrotyrosine-modified proteins are frequently detected in Alzheimer’s disease, Parkinson’s disease, and ALS, where they correlate with inflammation-induced tissue injury. Enzymes such as myeloperoxidase, cytochrome P450s, and superoxide dismutase catalyze tyrosine nitration, disrupting protein function and contributing to neuronal damage. As a marker of oxidative and nitrosative stress, nitrotyrosine provides mechanistic insight into redox imbalance and may serve as a diagnostic and therapeutic target in neurodegeneration.
0.7 µg/ml of SMC-154 was sufficient for detection of 5 µg SIN-1 treated BSA by Western Blot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Cite this product varies by variant:
- SMC-154D — Size: 100 ug: Nitrotyrosine Antibody (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-154D, RRID: AB_904533)
- SMC-154D-A390 — Size: 100 ug: Nitrotyrosine Antibody: ATTO 390 (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-154D-A390, RRID: AB_2698466)
- SMC-154D-A488 — Size: 100 ug: Nitrotyrosine Antibody: ATTO 488 (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-154D-A488, RRID: AB_2698467)
- SMC-154D-A594 — Size: 100 ug: Nitrotyrosine Antibody: ATTO 594 (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-154D-A594, RRID: AB_2698469)
- SMC-154D-APC — Size: 100 ug: Nitrotyrosine Antibody: APC (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-154D-APC, RRID: AB_2698475)
- SMC-154D-BI — Size: 100 ug: Nitrotyrosine Antibody: Biotin (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-154D-BI, RRID: AB_2698476)
- SMC-154D-FITC — Size: 100 ug: Nitrotyrosine Antibody: FITC (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-154D-FITC, RRID: AB_2698477)
- SMC-154D-HRP — Size: 100 ug: Nitrotyrosine Antibody: HRP (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-154D-HRP, RRID: AB_2698478)
- SMC-154D-PCP — Size: 100 ug: Nitrotyrosine Antibody: PerCP (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-154D-PCP, RRID: AB_2698480)
- SMC-154D-RPE — Size: 100 ug: Nitrotyrosine Antibody: RPE (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-154D-RPE, RRID: AB_2698481)
- SMC-154S — Size: 12 ug: Nitrotyrosine Antibody (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-154S, RRID: AB_904533)
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
2. Gow AJ, Farkouh CR, Munson DA, Posencheq MA, and Ischiropoulos H. (2004). Am J Physiol Lung Cell Mol Physiol. 287(2): L262-8.
3. Takemoto K. et al (2007). Acta Med Okayama 61(1): 17-30.
4. Reynolds MR. et al. (2006) J Nerosci. 26(42): 10636-45.
5. Pfister H., et al. (2002) Vet Pathol. 39: 190-199.
6. Khan J. et al. (1998) Biochem J. 330(2): 795-801.
